ArticleJournal of thoracic disease2017
Multimodality treatment of stage II thymic tumours.
Article in Journal of thoracic disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- The effectiveness of adjuvant radiotherapy after thymoma resection: a systematic review and meta-analysis.World journal of surgical oncology · 2025Pooled it
- Review
- Multimodality approach in treatment of thymic tumors.Journal of thoracic disease · 2020Review
- Development of a deep learning model for classifying thymoma as Masaoka-Koga stage I or II via preoperative CT images.Annals of translational medicine · 2020Article
- Assessment of the prognostic role of neutrophil-to-lymphocyte ratio following complete resection of thymoma.Journal of cardiothoracic surgery · 2018Article
- Wind of change in surgical treatment of thymic tumors.Journal of thoracic disease · 2018Article
- Extended resections of large thymomas: importance ofJournal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComplete resection for stage II thymic tumors can be easily accomplished even if the capsula and adjacent mediastinal tissue are macroscopically involved; however, also at this stage, recurrence may occur, particularly for B2, B3 and thymic carcinoma. The criteria for the administration of adjuvant therapy remain controversial and it is unclear whether patients at this stage may benefit from it. We reviewed a series of patients at this stage receiving adjuvant chemo-radiotherapy (chemo-RT) based on histology.
methodsEighty-eight consecutive patients with stage II thymic tumors were reviewed; 59 patients (67%) with B thymoma or thymic carcinoma received adjuvant treatment with mediastinal irradiation (40-55 Gy), chemotherapy (CH) (PAC regimen) or a combination of both.
resultsComplete resection was achieved in all patients. Fifty-four patients (61%) received post-operative chemo-RT, 2 (2%) patients received adjuvant CH only and 3 (3%) post-operative RT only; they all had B2, B3 histology or thymic carcinoma. The median follow up was 107±83 months. 5-year and 10-year survival were 96%±2% and 83.4%±5%. Recurrence was observed in 5 patients (5.7%). Disease-free 5 and 10-year survival was 94%±2% and 92%±3% respectively. Five patients (5.7%) had recurrence.
conclusionsThe administration of adjuvant chemo-RT to patients with stage II type B thymoma and thymic carcinoma contributes to reduce the recurrence rate and to increase long-term survival.
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