ArticleJournal of thoracic disease2017
Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids.
Article in Journal of thoracic disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Medication Adherence Patterns for Patients with Atrial Fibrillation: A Mixed Methods Study to Understand Patient and Clinician Perspectives.Patient preference and adherence · 2026Article
- Trust in physicians as a mediator of the relationship between person-centered care and medication adherence in patients undergoing hemodialysis: a cross-sectional study.Journal of nephrology · 2025Article
- Evaluating Treatment Adherence in Children and Adolescents with Type 1 Diabetes: The Impact of the Adherence Starts with Knowledge-12 Score on Metabolic Control.Children (Basel, Switzerland) · 2025Article
- Nonadherence to antiasthmatic medications and its predictors among asthmatic patients in public hospitals of Bahir Dar City, North West Ethiopia: using ASK-12 tool.Asthma research and practice · 2023Article
- The Roles of Busyness and Daily Routine in Medication Management Behaviors Among Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- The impact of adherence and therapy regimens on quality of life in patients with congenital adrenal hyperplasia.Clinical endocrinology · 2022Article
- Barriers to adherence to iron chelation therapy among adolescent with transfusion dependent thalassemia.Frontiers in pediatrics · 2022Article
- Identifying the Causes Increasing the Risk of Non-Adherence in Adult Patients with Asthma: An Analysis Combining Patient Survey Data with German Claims Data.Drugs - real world outcomes · 2021Article
- Assessment of medication adherence in children and adults with congenital adrenal hyperplasia and the impact of knowledge and self-management.Clinical endocrinology · 2021Article
- Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study.Journal of medical Internet research · 2020Observational
- Article
- Once-daily fluticasone furoate/vilanterol combination versus twice-daily budesonide/formoterol combination in the treatment of controlled stable asthma: a randomized crossover trial.Journal of asthma and allergy · 2019Review
- Effectiveness of Chinese herbal medicine Ping Chuan Ke Li for the management of mild/moderate persistent asthma.Medicine · 2018Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-adherence to inhalation regimens is common in asthmatic patients. The Adherence Starts with Knowledge-12 (ASK-12) survey was developed to detect and address patient-specific barriers to medication adherence. Our objective is to investigate the clinical usefulness of the ASK-12 for assessing and addressing adherence to inhalation therapy in asthma.
methodsThe ASK-12 was administered to 138 asthmatic patients. Using pharmacy-refill data, we examined the cut-off value of the ASK-12 to identify patients who were non-adherent to inhalation regimens and identify factors associated with non-adherence. To verify the usefulness of the ASK-12, inhalation regimens were prospectively switched to less-expensive and simpler (once-daily) dosing regimens in eight non-adherent asthmatic patients who reported specific-barriers in "inconvenience of twice-daily inhaler use" and "cost".
resultsValid responses were received from 114 (82.6%) patients. A significant correlation was found between pharmacy-refill rates and the ASK-12 total score (r=-0.55, P<0.0001). The optimal cut-off value of the ASK-12 total score to discriminate non-adherent patients (defined by pharmacy-refill rate <80%) was 23, with 71.4% specificity and 93.3% sensitivity. Using this value, 52 (45.6%) patients were classified as non-adherent. Univariate followed by multivariate analysis identified younger age as a predictor of non-adherence to inhalation regimens (odds ratio, 2.67; 95% CI, -0.95 to -0.06; P=0.027). Switching inhaled medicines in eight patients resulted in significant improvements in both ASK-12 scores and asthma control.
conclusionsThe ASK-12 is a brief, practical, and clinically useful measure for assessing and addressing adherence to inhalation regimens in asthma.
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