ArticleClinical diabetes and endocrinology2017
A clinician's guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms.
Article in Clinical diabetes and endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Clinical and laboratory characteristics of pediatric patients diagnosed with thyroid hormone resistance: A single-center experience.Endocrine · 2026Observational
- Review
- A case of thyroid hormone resistance with coincidental pituitary macroadenoma.JCEM case reports · 2026Article
- A case of thyroid hormone resistance with thyroid regrowth: implications of misdiagnosis on patient care.JCEM case reports · 2026Article
- In silico development of RNA aptamer candidates against thyroid receptor.Journal of computer-aided molecular design · 2025Article
- Global impact of micronutrients in modern human evolution.American journal of human genetics · 2025Article
- Roxadustat Activates Thyroid Hormone Receptors α and β at Clinically Relevant Concentrations.Cureus · 2025Article
- Clinical Characteristics and Genotype-phenotype Correlation in Turkish Patients with a Diagnosis of Resistance to Thyroid Hormone BetaJournal of clinical research in pediatric endocrinology · 2025Article
- New Insights in the Diagnostic Potential of Sex Hormone-Binding Globulin (SHBG)-Clinical Approach.Biomedicines · 2025Review
- Late-Onset Thyroid Hormone Resistance Following Total Thyroidectomy for Papillary Thyroid Cancer.Cureus · 2025Article
- Audiological alterations in resistance to thyroid hormone syndrome: emphasizing lifelong assessment.Archives of endocrinology and metabolism · 2025Article
- Resistance to Thyroid Hormone Beta and Coexisting Thyroid Disease: Diagnostic and Therapeutic Challenges Illustrated by Two Cases.Case reports in endocrinology · 2025Article
- Complementary and additive functions of TRα and TRβ during intestinal remodeling as revealed by ChIP-Seq analysis on wild type and TR knockout animals.General and comparative endocrinology · 2025Article
- Nuclear receptor corepressor 1 levels differentially impact the intracellular dynamics of mutant thyroid hormone receptors associated with resistance to thyroid hormone syndrome.Molecular and cellular endocrinology · 2024Article
- Thyroid Hormone Resistance With a Novel Mutation.Cureus · 2024Article
- Resistance to Thyroid Hormone Beta Due toJCEM case reports · 2024Article
- Metabolic Messengers: Thyroid Hormones.Nature metabolism · 2024Review
- Resistance to thyroid hormone and nonfunctioning pituitary microadenoma in a 13-year-old boy with THRB mutation.Annals of pediatric endocrinology & metabolism · 2024Article
- R243W Mutation in Thyroid Hormone Resistance Syndrome Beta: A Case Report.Journal of the ASEAN Federation of Endocrine Societies · 2024Article
- Thyroid Hormone Resistance Syndrome: From Molecular Mechanisms to Its Potential Contribution to Hypertension.Cureus · 2023Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are two genes that express the major thyroid hormone receptor isoforms. Mutations in both these genes have given rise to Resistance to Thyroid Hormone (RTH) syndromes (RTHβ, RTHα) that can have variable phenotypes for mutations of the same receptor isoform as well as between the two receptor isoforms. In general, the relative tissue-specific distribution of TRβ and TRα determine RTH in different tissues for each form of RTH. These differences highlight some of the isoform-specific roles of each TR isoform. The diagnosis of RTH is challenging for the clinician but should be considered whenever a patient presents with unexplained elevated serum free T
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