ArticleCaspian journal of internal medicine2017
Cancer risk among patients with multiple sclerosis: A cohort study in Isfahan, Iran.
Article in Caspian journal of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications.Journal of neurology · 2021Pooled it
- The Sanctuary Within: Development of CD20+ CNS Lymphoma Despite Peripheral B-Cell Depletion by Rituximab in a Multiple Sclerosis Patient.Case reports in neurological medicine · 2026Article
- Patient stratification reveals the molecular basis of disease co-occurrences.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fingolimod and risk of skin cancer among individuals with multiple sclerosis: a population-based cohort study protocol.BMJ open · 2025Article
- Cancer Risk Among Patients With Multiple Sclerosis: A 10-Year Nationwide Retrospective Cohort Study.Neurology · 2024Article
- Cancer and mortality risks among people with multiple sclerosis: A population-based study in Isfahan, Iran.PloS one · 2024Article
- Is cancer risk reduced in multiple sclerosis? Results from a tertiary referral center.Turkish journal of medical sciences · 2023Article
- Multiple sclerosis and breast cancer risk: a meta-analysis of observational and Mendelian randomization studies.Frontiers in neuroinformatics · 2023Article
- Increasing cancer risk over calendar year in people with multiple sclerosis: a case-control study.Journal of neurology · 2021Article
- Breast Carcinoma After Ocrelizumab Therapy in Multiple Sclerosis Patients: A Case Series and Literature Review.Journal of central nervous system disease · 2021Article
- Multiple sclerosis, human herpesvirus 4 and thyroid collision tumor: A case report.Experimental and therapeutic medicine · 2020Article
- Cancer Risk and Multiple Sclerosis: Evidence From a Large Italian Cohort.Frontiers in neurology · 2019Article
- Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies.Frontiers in immunology · 2019Review
- Interleukin 18 Polymorphisms and its serum level in Patients with Multiple Sclerosis.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS), a central nervous system (CNS) autoimmune disorder, affects 2.3 million people around the world. Cancer kills around 7.5 million people annually. Both diseases have similar risks and intertwining molecular causes. Most studies focusing on MS and cancer have found an insignificant difference or reduction in the amount of cancer found in the MS community.
methodsWe performed a cohort study using data from Isfahan Multiple Sclerosis Society (IMSS) and Isfahan cancer society and followed-up for 8 years on average (2006-2014). All of the 1718 MS patients were diagnosed according to McDonald's criteria, then standardized incidence ratio and the numbers of expected cancer case were calculated.
resultsWhile patients had an insignificant change in cancer prevalence, men had fewer cancer cases and women showed an increased prevalence of cancer. Certain types of cancer proved statistically significant. Breast cancer, nervous system cancers, and lymphoma were elevated in the cohort.
conclusionOur results support the hypothesis that MS significantly affects certain cancers in a protective or associative manner. All cancer rates, except breast cancer, cancers located in the nervous system, and lymphomas were reduced in cohort, suggesting that unregulated immune function may provide protective effects to MS patients against cancer.
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