ArticleOpen access Macedonian journal of medical sciences2017
The Effect of Three Different Biomaterials on Proliferation and Viability of Human Dental Pulp Stem Cells (In-vitro Study).
Article in Open access Macedonian journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis.Biomedical engineering online · 2024Pooled it
- A regenerative strategy for vital pulp therapy: Platelet-rich fibrin augments stem cell viability and pluripotency in bioactive cement environments.Biochemistry and biophysics reports · 2026Article
- Cytotoxicity of hydraulic cement dicalcium silicate mixture of eggshell calcium and rice husk silica on fibroblast cells.Journal of conservative dentistry and endodontics · 2025Article
- Review
- Comparative study of nanohydroxyapatite-emdogain effects on apical papilla stem cell survival and differentiation.Biotechnology letters · 2025Article
- Comparative evaluation of cytotoxic effects of a new biomaterial nanohydroxyapatite-lactoferrin, nanohydroxyapatite, mineral trioxide aggregate, and calcium-enriched mixture on human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2025Article
- Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds.ACS materials Au · 2024Article
- Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells.Materials today. Bio · 2023Review
- Effectiveness of Three Agents in Pulpotomy Treatment of Permanent Molars with Incomplete Root Development: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2022Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Comparative evaluation of the effects of three hydraulic calcium silicate cements on odontoblastic differentiation of human dental pulp stem cells: an in vitro study.Journal of applied oral science : revista FOB · 2022Article
- Review
- Evaluation of the adhesion of human dental pulp stem cells to different endodontic biomaterials before and after setting.Journal of dental research, dental clinics, dental prospects · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiomaterial cytotoxicity on dental stem cells plays a critical role in managing the regeneration of dental tissue.
aimThe aim of the present study was to evaluate the effect of Nano-hydroxy apatite (NHA), Mineral trioxide aggregate (MTA), and Calcium-enriched mixture (CEM) on the proliferation, and viability of human dental pulp stem cells (hDPSCs) isolated from third molar teeth.
methodsCultured DPSCs were characterized and the tested biomaterials were shaped into cylinders then inserted directly on the DPSCs. Proliferation and viability percentage of DPSCs were evaluated at 1, 3, 5, 7, 9, 11, and 14 days of culture.
resultsThe biomaterials supplemented DPSCs showed a significant initial decrease in cell count and viability percentage at day one. Then, a rise in cell counts and viabilities was noticed after that. There was a decrease in cell counts, and viabilities in the NHA supplemented cells in comparison to other tested biomaterials.
conclusionsAll tested biomaterials maintain the proliferation of DPSCs for different durations. NHA showed less proliferative and more cytotoxic effect than other tested materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.