Evidence map›Paper›PMID 28932200›Full record

ArticleFrontiers in physiology2017

Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?

Laura Hertz, Rick Huisjes, Esther Llaudet-Planas, Polina Petkova-Kirova, Asya Makhro, Jens G Danielczok, Stephane Egee, Maria Del Mar Mañú-Pereira, Richard van Wijk, Joan-Lluis Vives Corrons and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
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  5. The uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) may enhance eryptosis and increase erythrocyte osmotic fragility through potential activation of PIEZO1.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  6. Review
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  8. Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
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  11. Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
    Review
  12. Article
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  15. CaInternational journal of molecular sciences · 2022
    Review
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  19. AHaematologica · 2021
    Article
  20. Lab on a chip · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 6 countries.

Laura HertzResearch Centre for Molecular Imaging and Screening, Medical School, Saarland UniversityHomburg, Germany.
Rick HuisjesDepartment of Clinical Chemistry and Haematology, University Medical Center UtrechtUtrecht, Netherlands.
Esther Llaudet-PlanasRed Blood Cell Defects and Hematopoietic Disorders Unit, Josep Carreras Leukaemia Research InstituteBarcelona, Spain.
Polina Petkova-KirovaResearch Centre for Molecular Imaging and Screening, Medical School, Saarland UniversityHomburg, Germany.
Asya MakhroRed Blood Cell Research Group, Institute of Veterinary Physiology, Vetsuisse Faculty and the Zurich Center for Integrative Human Physiology (ZIHP), University of ZurichZurich, Switzerland.
Jens G DanielczokResearch Centre for Molecular Imaging and Screening, Medical School, Saarland UniversityHomburg, Germany.
Stephane EgeeCentre National de la Recherche Scientifique, UMR 8227 Comparative Erythrocyte's PhysiologyRoscoff, France.
Maria Del Mar Mañú-PereiraRed Blood Cell Defects and Hematopoietic Disorders Unit, Josep Carreras Leukaemia Research InstituteBarcelona, Spain.
Richard van WijkDepartment of Clinical Chemistry and Haematology, University Medical Center UtrechtUtrecht, Netherlands.
Joan-Lluis Vives CorronsRed Blood Cell Defects and Hematopoietic Disorders Unit, Josep Carreras Leukaemia Research InstituteBarcelona, Spain.
Anna BogdanovaRed Blood Cell Research Group, Institute of Veterinary Physiology, Vetsuisse Faculty and the Zurich Center for Integrative Human Physiology (ZIHP), University of ZurichZurich, Switzerland.
Lars KaestnerTheoretical Medicine and Biosciences, Saarland UniversityHomburg, Germany.
Saarland University · DEJosep Carreras Leukaemia Research Institute · ESUniversity Medical Center Utrecht · NLUniversity of Zurich · CHCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For many hereditary disorders, although the underlying genetic mutation may be known, the molecular mechanism leading to hemolytic anemia is still unclear and needs further investigation. Previous studies revealed an increased intracellular Ca

Indexed as

calcium homeostasischannelopathieserythrocytelive cell imagingrare anemiaspherocytosisxerocytosis

Identifiers

PMID28932200
PMCPMC5592231
OpenAlexW2752172602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.