ArticleInternational journal of nanomedicine2017
Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Iron-Loaded Carbon Spherogels as Sustainable Electrode Materials for High-Performance Lithium-Ion Batteries.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Drug Delivery Opportunities in Esophageal Cancer: Current Treatments and Future Prospects.Molecular pharmaceutics · 2024Review
- Black goes green: single-step solvent exchange for sol-gel synthesis of carbon spherogels as high-performance supercapacitor electrodes.Energy advances · 2024Article
- High-Performance Lithium-Ion Batteries with High Stability Derived from Titanium-Oxide- and Sulfur-Loaded Carbon Spherogels.ACS applied materials & interfaces · 2024Article
- An Alternating Magnetic Field-Controlled Drug Delivery System Based on 4,4'-Azobis (4-cyanovaleric Acid)-Functioned FeBioengineering (Basel, Switzerland) · 2023Article
- Application and development of nanomaterials in the diagnosis and treatment of esophageal cancer.Frontiers in bioengineering and biotechnology · 2023Review
- Advances and challenges in the treatment of esophageal cancer.Acta pharmaceutica Sinica. B · 2021Review
- Synthesis and Characterization of Novel Hybrid Flocculants Based on Potato Starch Copolymers with Hollow Carbon Spheres.Materials (Basel, Switzerland) · 2021Article
- Nitrogen-phosphorus doped graphitic nano onion-like structures: experimental and theoretical studies.RSC advances · 2021Article
- Carbon Based Nanodots in Early Diagnosis of Cancer.Frontiers in chemistry · 2021Review
- Construction of Biocompatible Dual-Drug Loaded Complicated Nanoparticles forFrontiers in oncology · 2020Article
- Current trends and challenges in cancer management and therapy using designer nanomaterials.Nano convergence · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment. The HCSs also displayed excellent immunocompatibility and could rapidly distribute themselves in the cytoplasm to escape lysosomal clearance. More importantly, the HCSs could efficiently deliver doxorubicin (a representative chemotherapeutic drug) to tumor sites, which resulted in significant inhibition of tumor growth in an esophageal xenograft cancer model. This also prolonged the circulation time and altered the biodistribution of the drug. In conclusion, this study revealed a novel drug delivery system for targeted tumor therapy.
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