ArticleScientific reports2017
Disrupted topological organization of structural brain networks in childhood absence epilepsy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00600717 (Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals
Who cites it
14 citing papers in PubMed.
- Individualized morphological covariation network aberrance associated with seizure relapse after antiseizure medication withdrawal.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Transcutaneous auricular vagus nerve stimulation for long-term post-stroke cognitive impairment: a DTI case report.Frontiers in human neuroscience · 2024Article
- Exploring brain network oscillations during seizures in drug-naïve patients with juvenile absence epilepsy.Frontiers in neurology · 2024Article
- Exploring the core network of the structural covariance network in childhood absence epilepsy.Heliyon · 2023Article
- Impaired rich-club connectivity in childhood absence epilepsy.Frontiers in neurology · 2023Article
- Temporal and spatial dynamic propagation of electroencephalogram by combining power spectral and synchronization in childhood absence epilepsy.Frontiers in neuroinformatics · 2022Article
- Frequency-Dependent Dynamics of Functional Connectivity Networks During Seizure Termination in Childhood Absence Epilepsy: A Magnetoencephalography Study.Frontiers in neurology · 2021Article
- Functional network topology in drug resistant and well-controlled idiopathic generalized epilepsy: a resting state functional MRI study.Brain communications · 2021Article
- Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures.Brain and behavior · 2020Article
- Altered Structural Network in Newly Onset Childhood Absence Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2020Article
- Functional brain network characteristics are associated with epilepsy severity in childhood absence epilepsy.NeuroImage. Clinical · 2020Article
- Optimization of surgical intervention outside the epileptogenic zone in the Virtual Epileptic Patient (VEP).PLoS computational biology · 2019Article
- Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study.Neuroradiology · 2019Article
- Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.Frontiers in neuroanatomy · 2018Review
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Authors and funding
10 authors.
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Abstract
Childhood absence epilepsy (CAE) is the most common paediatric epilepsy syndrome and is characterized by frequent and transient impairment of consciousness. In this study, we explored structural brain network alterations in CAE and their association with clinical characteristics. A whole-brain structural network was constructed for each participant based on diffusion-weighted MRI and probabilistic tractography. The topological metrics were then evaluated. For the first time, we uncovered modular topology in CAE patients that was similar to healthy controls. However, the strength, efficiency and small-world properties of the structural network in CAE were seriously damaged. At the whole brain level, decreased strength, global efficiency, local efficiency, clustering coefficient, normalized clustering coefficient and small-worldness values of the network were detected in CAE, while the values of characteristic path length and normalized characteristic path length were abnormally increased. At the regional level, especially the prominent regions of the bilateral precuneus showed reduced nodal efficiency, and the reduction of efficiency was significantly correlated with disease duration. The current results demonstrate significant alterations of structural networks in CAE patients, and the impairments tend to grow worse over time. Our findings may provide a new way to understand the pathophysiological mechanism of CAE.
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