ArticleNature communications2017
Optical trapping of otoliths drives vestibular behaviours in larval zebrafish.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Heart rate control by listening to light.Nature communications · 2026Article
- Light force-powered cellular medical micromachines.Frontiers in bioengineering and biotechnology · 2026Review
- Article
- FAIR data for optical tweezers experiments.Biophysical journal · 2025Review
- Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Instrumented swim test for quantifying motor impairment in rodents.Scientific reports · 2024Article
- Tuning collective behaviour in zebrafish with genetic modification.PLoS computational biology · 2024Article
- Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.ACS photonics · 2024Review
- Ultrasound-induced reorientation for multi-angle optical coherence tomography.Nature communications · 2024Article
- A vibrating capillary for ultrasound rotation manipulation of zebrafish larvae.Lab on a chip · 2024Article
- Raman cell sorting for single-cell research.Frontiers in bioengineering and biotechnology · 2024Review
- Organization of vestibular circuits for postural control in zebrafish.Current opinion in neurobiology · 2023Review
- Optofluidic Tweezers: Efficient and Versatile Micro/Nano-Manipulation Tools.Micromachines · 2023Review
- The Nature and Origin of Synaptic Inputs to Vestibulospinal Neurons in the Larval Zebrafish.eNeuro · 2023Article
- The nature and origin of synaptic inputs to vestibulospinal neurons in the larval zebrafish.bioRxiv : the preprint server for biology · 2023Article
- Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish.Nature communications · 2023Article
- Optical trapping with holographically structured light for single-cell studies.Biophysics reviews · 2023Review
- Vestibular physiology and function in zebrafish.Frontiers in cell and developmental biology · 2023Review
- Optical tweezers across scales in cell biology.Trends in cell biology · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vestibular system, which detects gravity and motion, is crucial to survival, but the neural circuits processing vestibular information remain incompletely characterised. In part, this is because the movement needed to stimulate the vestibular system hampers traditional neuroscientific methods. Optical trapping uses focussed light to apply forces to targeted objects, typically ranging from nanometres to a few microns across. In principle, optical trapping of the otoliths (ear stones) could produce fictive vestibular stimuli in a stationary animal. Here we use optical trapping in vivo to manipulate 55-micron otoliths in larval zebrafish. Medial and lateral forces on the otoliths result in complementary corrective tail movements, and lateral forces on either otolith are sufficient to cause a rolling correction in both eyes. This confirms that optical trapping is sufficiently powerful and precise to move large objects in vivo, and sets the stage for the functional mapping of the resulting vestibular processing.The neural circuits of the vestibular system, which detects gravity and motion, remain incompletely characterised. Here the authors use an optical trap to manipulate otoliths (ear stones) in zebrafish larvae, and elicit corrective tail movements and eye rolling, thus establishing a method for mapping vestibular processing.
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