SynthesisNature communications2017
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Assessing the lack of diversity in genetics research across neurodegenerative diseases: A systematic review of the GWAS Catalog and literature.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Association between type 2 diabetes and amyotrophic lateral sclerosis.Scientific reports · 2022Pooled it
- Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.Nature genetics · 2021Pooled it
- A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.Communications biology · 2020Pooled it
- Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.Human molecular genetics · 2018Pooled it
- A new era of genome-wide association studies in the field of Alzheimer's disease and overlapping co-pathologies: lessons learned from a neuropathology-centered approach.Acta neuropathologica · 2026Review
- Shared genetic architecture between DTI-ALPS traits and neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci.medRxiv : the preprint server for health sciences · 2026Article
- Review of the Pathology of Muscle in Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2026Review
- An in silico protocol for predicting genetic biomarkers in rare diseases: a case study in sporadic amyotrophic lateral sclerosis.Frontiers in genetics · 2026Article
- Classical HLA class II associations with ALS in Kuwait reveal a DR7-DQ2.2 risk haplotype.Frontiers in immunology · 2026Article
- Amyotrophic Lateral Sclerosis and Risk of Common Cancer: Mendelian Randomization Interrogation of Causality and Mediation.Phenomics (Cham, Switzerland) · 2025Article
- Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.Nature communications · 2025Article
- Identification of novel candidate loci for Alzheimer's disease and related dementias by leveraging the shared genetic basis with hippocampal volume.Aging brain · 2025Article
- GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing.Science immunology · 2024Article
- Glutathione peroxidase 3 is a potential biomarker for konzo.Nature communications · 2024Article
- Discovery and Exploration of Lipid-Modifying Drug Targets for ALS by Mendelian Randomization.Molecular neurobiology · 2024Article
- Review
- Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer's disease progression.Communications biology · 2024Article
- Cross-ancestry genetic architecture and prediction for cholesterol traits.Human genetics · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors.
Beben BenyaminQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Ji HeDepartment of Neurology, Peking University, Third Hospital, No. 49, North Garden Road, Haidian District, 100191, Beijing, China.
Qiongyi ZhaoQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0002-6341-0416
Jacob GrattenQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Fleur GartonQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Paul J LeoUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Zhijun LiuQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Marie MangelsdorfQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Ammar Al-ChalabiDepartment of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, WC2 R2LS, UK.ORCID http://orcid.org/0000-0002-4924-7712
Lisa AndersonUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Timothy J ButlerQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Lu ChenDepartment of Neurology, Peking University, Third Hospital, No. 49, North Garden Road, Haidian District, 100191, Beijing, China.
Xiang-Ding ChenLaboratory of Molecular and Statistical Genetics and State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China.
Katie CreminUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Hong-Weng DengDepartment of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Center for Bioinformatics and Genomics, Tulane University, 1440 Canal St, Suite 2001, New Orleans, LA, 70112, USA.
Matthew DevineDepartment of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Queensland, 4029, Australia.
Janette EdsonQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Jennifer A FifitaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia.
Sarah FurlongQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Ying-Ying HanCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, 334, Jungong Road, Yangpu District, 200093, Shanghai, China.
Jessica HarrisUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Anjali K HendersQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Rosalind L JeffreeKenneth G. Jamieson Department of Neurosurgery, Royal Brisbane & Women's Hospital, Herston, Queensland, 4029, Australia.
Zi-Bing JinDivision of Ophthalmic Genetics, Laboratory for Stem Cell and Retinal Regeneration, The Eye Hospital of Wenzhou Medical University, 325027, Wenzhou, China.
Zhongshan LiInstitute of Genomic Medicine, Wenzhou Medical University, 325027, Wenzhou, China.
Ting LiDepartment of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University, 200003, Shanghai, China.
Mengmeng LiDepartment of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University, 200003, Shanghai, China.
Yong LinCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, 334, Jungong Road, Yangpu District, 200093, Shanghai, China.
Xiaolu LiuDepartment of Neurology, Peking University, Third Hospital, No. 49, North Garden Road, Haidian District, 100191, Beijing, China.
Mhairi MarshallUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Emily P McCannDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia.
Bryan J MowryQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Shyuan T NgoQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0002-1388-2108
Roger PamphlettStacey MND Laboratory, Discipline of Pathology, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, 2006, Australia.
Shu RanCenter of System Biomedical Sciences, University of Shanghai for Science and Technology, 334, Jungong Road, Yangpu District, 200093, Shanghai, China.
David C ReutensThe Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Dominic B RoweDepartment of Medicine, Faculty of Medicine and Health Sciences, Multidisciplinary Motor Neurone Disease Clinic, Macquarie University, Sydney, New South Wales, 2109, Australia.
Perminder SachdevCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, 2052, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Sonia ShahQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Sharon SongUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Li-Jun TanLaboratory of Molecular and Statistical Genetics and State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China.
Lu TangDepartment of Neurology, Peking University, Third Hospital, No. 49, North Garden Road, Haidian District, 100191, Beijing, China.
Leonard H van den BergDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
Wouter van RheenenDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
Jan H VeldinkDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
Robyn H WallaceQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Lawrie WheelerUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Kelly L WilliamsDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia.ORCID http://orcid.org/0000-0001-6319-9473
Jinyu WuInstitute of Genomic Medicine, Wenzhou Medical University, 325027, Wenzhou, China.
Xin WuDepartment of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University, 200003, Shanghai, China.
Jian YangQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.ORCID http://orcid.org/0000-0003-2001-2474
Weihua YueInstitute of Mental Health, The Sixth Hospital, Peking University, 100191, Beijing, China.
Zong-Hong ZhangQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Dai ZhangInstitute of Mental Health, The Sixth Hospital, Peking University, 100191, Beijing, China.
Peter G NoakesDepartment of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Queensland, 4029, Australia.
Ian P BlairDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia.
Robert D HendersonQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Pamela A McCombeDepartment of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Queensland, 4029, Australia.
Peter M VisscherQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Huji XuDepartment of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medical University, 200003, Shanghai, China.
Perry F BartlettQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Matthew A BrownUniversity of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
Naomi R WrayQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia. naomi.wray@uq.edu.au.ORCID http://orcid.org/0000-0001-7421-3357
Dongsheng FanDepartment of Neurology, Peking University, Third Hospital, No. 49, North Garden Road, Haidian District, 100191, Beijing, China.
Funding
Medical Research Council MR/L501529/1Motor Neurone Disease Association ALCHALABI-DOBSON/APR14/829-791
Abstract
Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele frequency patterns across ethnic groups may increase gene-mapping resolution. Here we use cross-ethnic genetic data in sporadic amyotrophic lateral sclerosis (ALS), an adult-onset, rapidly progressing neurodegenerative disease. We report analyses of novel genome-wide association study data of 1,234 ALS cases and 2,850 controls. We find a significant association of rs10463311 spanning GPX3-TNIP1 with ALS (p = 1.3 × 10
Indexed as
Amyotrophic Lateral SclerosisAsian PeopleAustraliaChinaDNA-Binding ProteinsGenome-Wide Association StudyGlutathione PeroxidaseHigh-Throughput Nucleotide SequencingHumansSequence Analysis, DNAWhite PeopleDNA-Binding ProteinsGlutathione PeroxidaseGPX3 protein, humanTNIP1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.