ArticleScience translational medicine2017
Neutrophil transfer of
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Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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0cells of the map it votes in
118citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
118 citing papers in PubMed, 171 citations in OpenAlex.
- The role of myeloid immune cells in lung epithelial repair.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Cell-type Specific Alteration ofbioRxiv : the preprint server for biology · 2026Article
- MicroRNAs as current diagnostic biomarkers and potential therapeutic targets in allergic and non-allergic rhinitis - A functional characterization.Current allergy and asthma reports · 2026Review
- Ventilator-Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets.MedComm · 2026Review
- The Involvement of MicroRNAs in Innate Immunity and Cystic Fibrosis Lung Disease: A Narrative Review.Current issues in molecular biology · 2026Review
- miRNAs-neutrophil axis: novel insights into acute lung injury and chronic inflammatory lung diseases.Frontiers in immunology · 2026Review
- Advanced nanotherapies for precision treatment of inflammatory lung diseases.Bioactive materials · 2025Review
- Molecular signatures of alveolar type II cell differentiation in acute respiratory distress syndrome.Frontiers in medicine · 2025Article
- The MicroRNA miR-223 Constrains Colitis-associated Tumorigenesis by Limiting Myeloid Cell Infiltration and Chemokine Expression.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Patient-matched tumours, plasma, and cell lines reveal tumour microenvironment- and cell culture-specific microRNAs.Biology open · 2024Article
- Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury.Journal of nanobiotechnology · 2024Article
- Harnessing Extracellular microRNAs for Diagnostics and Therapeutics in Acute Systemic Inflammation.Cells · 2024Review
- Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair.American journal of physiology. Cell physiology · 2024Review
- Tiny Guides, Big Impact: Focus on the Opportunities and Challenges of miR-Based Treatments for ARDS.International journal of molecular sciences · 2024Review
- Role and mechanisms of autophagy, ferroptosis, and pyroptosis in sepsis-induced acute lung injury.Frontiers in pharmacology · 2024Review
- Exosome prospects in the diagnosis and treatment of non-alcoholic fatty liver disease.Frontiers in medicine · 2024Review
- A Comparative Analysis of MicroRNA Expression in Mild, Moderate, and Severe COVID-19: Insights from Urine, Serum, and Nasopharyngeal Samples.Biomolecules · 2023Article
- Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression.Translational psychiatry · 2023Article
- Exosomal miR-17-5p, miR-146a-3p, and miR-223-3p Correlate with Radiologic Sequelae in Survivors of COVID-19-Related Acute Respiratory Distress Syndrome.International journal of molecular sciences · 2023Article
- Extracellular vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-κB axis.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 7 institutions in 2 countries.
Viola NeudeckerOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA. viola.neudecker@med.uni-muenchen.de.ORCID http://orcid.org/0000-0003-3021-5523
Kelley S BrodskyOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0003-0732-7703
Eric T ClambeyOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0002-7972-9544
Eric P SchmidtOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.
Thomas A PackardDepartment of Immunology and Microbiology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA.ORCID http://orcid.org/0000-0003-4807-9101
Bennett DavenportOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.
Theodore J StandifordDivision of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Tingting WengDepartment of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, TX 77030, USA.
Ashley A FletcherDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0003-2626-4867
Lea BarthelDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.ORCID http://orcid.org/0000-0001-7897-1606
Joanne C MastersonSection of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, Digestive Health Institute, Children's Hospital Colorado; Mucosal Inflammation Program, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0002-8336-9879
Glenn T FurutaSection of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, Digestive Health Institute, Children's Hospital Colorado; Mucosal Inflammation Program, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0003-3262-3571
Chunyan CaiDepartment of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID http://orcid.org/0000-0002-7213-621X
Michael R BlackburnDepartment of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, TX 77030, USA.
Adit A GindeOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.
Michael W GranerDepartment of Neurosurgery, University of Colorado Denver, Aurora, CO 80045, USA.
William J JanssenOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0002-6397-3454
Rachel L ZemansDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.ORCID http://orcid.org/0000-0003-3537-9869
Christopher M EvansOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0001-5600-7314
Ellen L BurnhamDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID http://orcid.org/0000-0002-9945-0284
Dirk HomannOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.
Marc MossDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Simone KrethDepartment of Anesthesiology, University Hospital, Ludwig-Maximilian University of Munich, 81377 Munich, Germany.
Kai ZacharowskiDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, 60590 Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-0212-9110
Peter M HensonOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.
Holger K EltzschigOrgan Protection Program, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045, USA.
University of Colorado Denver · USNational Jewish Health · USThe University of Texas Health Science Center at Houston · USChildren's Hospital Colorado · USLudwig-Maximilians-Universität München · DEGoethe University Frankfurt · DEUniversity of Michigan · US
Funding
SCCOR in Translational Research in Acute Lung InjuryP50HL074024 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HYZY, ROBERT C · 2003 to 2007
$13.5MCenter for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4MTrangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLACKBURN, MICHAEL R · 2013 to 2017
$10.0MRole of Mucin in Lung Homeostasis and PathophysiologyR01HL080396 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Christopher M Evans · 2009 to 2026
$8.6MAdenosine Signaling and Lung FibrosisR01HL070952 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLACKBURN, MICHAEL R · 2002 to 2019
$5.7MMechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2MNovel Immunologic Effects of Semaphorin 7a in IPFR01HL109233 · NHLBI · YALE UNIVERSITY · PI HERZOG, ERICA L · 2011 to 2019
$3.7MMacrophage endocytosis in resolving lung inflammationR01HL114381 · NHLBI · NATIONAL JEWISH HEALTH · PI HENSON, PETER M · 2013 to 2016
$2.6MNovel IL-1 Family Members in Lung Innate ImmunityR01HL123515 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STANDIFORD, THEODORE J. · 2015 to 2018
$2.5MMechanisms of Repair of the Alveolar Epithelium after Lung InjuryR01HL131608 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZEMANS, RACHEL LYNNE · 2016 to 2020
$1.9MHypoxia-Inducible Factors in Acetaminophen-Induced Liver Injury.R01DK109574 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2016 to 2019
$1.8MProton Pump Inhibitors for Perioperative Acute Kidney InjuryR01DK097075 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2013 to 2017
$1.7MNCATS NIH HHS UL1 TR000371NHLBI NIH HHS P01 HL114457NHLBI NIH HHS P50 HL074024NHLBI NIH HHS R01 HL070952NHLBI NIH HHS R01 HL080396NHLBI NIH HHS R01 HL098294NHLBI NIH HHS R01 HL109233NHLBI NIH HHS R01 HL114381NHLBI NIH HHS R01 HL119837NHLBI NIH HHS R01 HL123515NHLBI NIH HHS R01 HL130938NHLBI NIH HHS R01 HL131608NHLBI NIH HHS R01 HL133900NIDDK NIH HHS R01 DK082509NIDDK NIH HHS R01 DK097075NIDDK NIH HHS R01 DK109574NIEHS NIH HHS R21 ES023384
Abstract
Intercellular transfer of microRNAs can mediate communication between critical effector cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial cells could alter mucosal gene expression during acute lung injury. Pulmonary-epithelial microRNA profiling during coculture of alveolar epithelial cells with polymorphonuclear neutrophils (PMNs) revealed a selective increase in lung epithelial cell expression of microRNA-223 (
Indexed as
Acute Lung InjuryAnimalsCell CommunicationEpithelial CellsGene Knockdown TechniquesHumansLungMice, Inbred C57BLMicroRNAsNanoparticlesNeutrophilsPneumoniaPoly(ADP-ribose) PolymerasesRNA TransportMicroRNAsMIRN223 microRNA, mousePoly(ADP-ribose) Polymerases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.