Evidence map›Paper›PMID 28931620›Full record

SynthesisStroke2017

Effects of Physical Activity on Poststroke Cognitive Function: A Meta-Analysis of Randomized Controlled Trials.

Lauren E Oberlin, Aashna M Waiwood, Toby B Cumming, Anna L Marsland, Julie Bernhardt, Kirk I Erickson

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  9. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lauren E OberlinFrom the Department of Psychology (L.E.O., A.M.W., A.L.M., K.I.E.), and Center for the Neural Basis of Cognition (L.E.O., K.I.E.), University of Pittsburgh, PA; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia (T.B.C, J.B.). leo11@pitt.edu.
Aashna M WaiwoodFrom the Department of Psychology (L.E.O., A.M.W., A.L.M., K.I.E.), and Center for the Neural Basis of Cognition (L.E.O., K.I.E.), University of Pittsburgh, PA; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia (T.B.C, J.B.).
Toby B CummingFrom the Department of Psychology (L.E.O., A.M.W., A.L.M., K.I.E.), and Center for the Neural Basis of Cognition (L.E.O., K.I.E.), University of Pittsburgh, PA; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia (T.B.C, J.B.).
Anna L MarslandFrom the Department of Psychology (L.E.O., A.M.W., A.L.M., K.I.E.), and Center for the Neural Basis of Cognition (L.E.O., K.I.E.), University of Pittsburgh, PA; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia (T.B.C, J.B.).
Julie BernhardtFrom the Department of Psychology (L.E.O., A.M.W., A.L.M., K.I.E.), and Center for the Neural Basis of Cognition (L.E.O., K.I.E.), University of Pittsburgh, PA; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia (T.B.C, J.B.).
Kirk I EricksonFrom the Department of Psychology (L.E.O., A.M.W., A.L.M., K.I.E.), and Center for the Neural Basis of Cognition (L.E.O., K.I.E.), University of Pittsburgh, PA; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia (T.B.C, J.B.).

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Investigating Gains in Neurocognition in an Intervention Trial of Exercise SupplementR01AG053952 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURNS, JEFFREY MURRAY, ERICKSON, KIRK I · 2016 to 2020
$27.5M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F · 2011 to 2015
$8.3M
Influence of Exercise on Neurocognitive Function in Breast CancerR01CA196762 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M., ERICKSON, KIRK I · 2016 to 2020
$3.0M
Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
Multimodal Neuroimaging Training ProgramT90DA022761 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GIANAROS, PETER J · 2006 to 2015
$988k
NCI NIH HHS R01 CA196762NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG053952NIDA NIH HHS T90 DA022761NIDDK NIH HHS R01 DK095172NIMH NIH HHS P30 MH090333
6 · The paper itself

Abstract

background and purposeDespite the social, health, and economic burdens associated with cognitive impairment poststroke, there is considerable uncertainty about the types of interventions that might preserve or restore cognitive abilities. The objective of this systematic review and meta-analysis was to evaluate the effects of physical activity (PA) training on cognitive function poststroke and identify intervention and sample characteristics that may moderate treatment effects.

methodsRandomized controlled trials examining the association between structured PA training and cognitive performance poststroke were identified using electronic databases EMBASE and MEDLINE. Intervention effects were represented by Hedges' g and combined into pooled effect sizes using random- and mixed-effects models. Effect sizes were subjected to moderation analyses using the between-group heterogeneity test.

resultsFourteen studies met inclusion criteria, representing data from 736 participants. The primary analysis yielded a positive overall effect of PA training on cognitive performance (Hedges' g [95% confidence interval]=0.304 [0.14-0.47]). Mixed-effects analyses demonstrated that combined aerobic and strength training programs generated the largest cognitive gains and that improvements in cognitive performance were achieved even in the chronic stroke phase (mean=2.6 years poststroke). Positive moderate treatment effects were found for attention/processing speed measures (Hedges' g [confidence interval]=0.37 [0.10-0.63]), while the executive function and working memory domains did not reach significance (

conclusionsWe found a significant positive effect of PA training on cognition poststroke with small to moderate treatment effects that are apparent even in the chronic stroke phase. Our findings support the use of PA training as a treatment strategy to promote cognitive recovery in stroke survivors.

Indexed as

CognitionExerciseModels, BiologicalFemaleHumansMaleRandomized Controlled Trials as TopicStrokecognitionexercisemeta-analysisphysical activitystrokesystematic review

Identifiers

PMID28931620
PMCPMC5784766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.