Evidence map›Paper›PMID 28931606›Full record

ArticleThe Journal of biological chemistry2017

Asparagine and glutamine ladders promote cross-species prion conversion.

Timothy D Kurt, Patricia Aguilar-Calvo, Lin Jiang, José A Rodriguez, Nazilla Alderson, David S Eisenberg, Christina J Sigurdson

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Unravelling the Complexity of Amyloid Peptide Core Interfaces.Journal of chemical information and modeling · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Glutamine Side ChainJournal of the American Chemical Society · 2019
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Timothy D KurtFrom the Departments of Pathology and Medicine, University of California at San Diego, La Jolla, California 92093.
Patricia Aguilar-CalvoFrom the Departments of Pathology and Medicine, University of California at San Diego, La Jolla, California 92093.
Lin Jiangthe Department of Neurology, UCLA, Los Angeles, California 90095, and.
José A Rodriguezthe UCLA-DOE Institute, Howard Hughes Medical Institute, Los Angeles, California 90095.
Nazilla AldersonFrom the Departments of Pathology and Medicine, University of California at San Diego, La Jolla, California 92093.
David S Eisenbergthe UCLA-DOE Institute, Howard Hughes Medical Institute, Los Angeles, California 90095.
Christina J SigurdsonFrom the Departments of Pathology and Medicine, University of California at San Diego, La Jolla, California 92093, csigurdson@ucsd.edu.
University of California, San Diego · USHoward Hughes Medical Institute · USInstitute of Molecular Biology · BG

Funding

Mechanisms of Prion Aggregation and Species BarriersR01NS069566 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, RAVITS, JOHN · 2011 to 2025
$5.7M
Structural Biology of Amyloid DiseaseR01AG029430 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EISENBERG, DAVID · 2007 to 2016
$3.9M
Mechanisms of Prion SpreadR01NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2012 to 2021
$3.4M
Mechanisms of Prion Spread and Neuronal ToxicityR37NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christina Sigurdson · 2023 to 2026
$2.6M
UCSD Research Training Program for VeterinariansT32OD017863 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERNST, PETER B., SIGURDSON, CHRISTINA · 2014 to 2023
$2.0M
Investigating molecular mechanisms of cross-species prion transmissionK01OD019919 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KURT, TIMOTHY DANIEL · 2015 to 2016
$176k
NIA NIH HHS R01 AG029430NIH HHS K01 OD019919NIH HHS T32 OD017863NINDS NIH HHS R01 NS069566NINDS NIH HHS R01 NS076896NINDS NIH HHS R37 NS076896
6 · The paper itself

Abstract

Prion transmission between species is governed in part by primary sequence similarity between the infectious prion aggregate, PrP

Indexed as

Amino Acid SubstitutionAmyloidAnimalsArvicolinaeAsparagineGlutamineHumansMice, Inbred C57BLModels, MolecularPrion DiseasesProtein Conformation, beta-StrandProtein StabilityPrPC ProteinsRabbitsAmyloidAsparagineGlutaminePrPC Proteinsamyloidfibrilneurodegenerationprionprion diseasesteric zippertransmission

Identifiers

PMID28931606
PMCPMC5704488
OpenAlexW2754230158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.