ArticleJournal of immunology (Baltimore, Md. : 1950)2017
Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors.
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development.Aging cell · 2026Article
- Whole-Thorax Irradiation Induces Persistent T Cell Clonal Dysregulation in Pediatric Rhesus Macaques.Radiation research · 2025Article
- Deinoxanthin Recovers HAntioxidants (Basel, Switzerland) · 2025Article
- Burning Down the House: Thymic Repair and Regeneration After Acute Damage.Immunological reviews · 2025Review
- Endogenous thymic regeneration: restoring T cell production following injury.Nature reviews. Immunology · 2025Review
- High-dose radiation preferentially induces the clonal expansion of hematopoietic progenitor cells over mature T and B cells in mouse bone marrow.Stem cell reports · 2025Article
- Neural Crest-Derived Mesenchymal Cells Support Thymic Reconstitution After Lethal Irradiation.European journal of immunology · 2025Article
- Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship.Blood cancer journal · 2024Article
- Primary and secondary defects of the thymus.Immunological reviews · 2024Review
- Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.Frontiers in immunology · 2024Article
- Application of mesenchymal stem cells for anti-senescence and clinical challenges.Stem cell research & therapy · 2023Review
- Whole bone subcutaneous transplantation as a strategy to study precisely the bone marrow niche.Stem cell reviews and reports · 2023Article
- Long-Term Immunological Consequences of Radiation Exposure in a Diverse Cohort of Rhesus Macaques.International journal of radiation oncology, biology, physics · 2023Article
- Induction of Accelerated Aging in a Mouse Model.Cells · 2022Review
- BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks.Nature communications · 2022Article
- T-Cell Progenitors As A New Immunotherapy to Bypass Hurdles of Allogeneic Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2022Review
- T cell regeneration after immunological injury.Nature reviews. Immunology · 2021Review
- Platelet gene therapy induces robust immune tolerance even in a primed model via peripheral clonal deletion of antigen-specific T cells.Molecular therapy. Nucleic acids · 2021Article
- Generation and Regeneration of Thymic Epithelial Cells.Frontiers in immunology · 2020Review
- Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation with aging remain unclear. In this study, we found that the impact of radiation on thymopoiesis in mice varied by sex and dose but, overall, thymopoiesis remained suppressed for ≥12 mo after a single exposure. Male and female mice showed a long-term dose-dependent reduction in thymic cKit
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Registered trials
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