Evidence map›Paper›PMID 28931574›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Enhanced Nociception in Angelman Syndrome Model Mice.

Eric S McCoy, Bonnie Taylor-Blake, Megumi Aita, Jeremy M Simon, Benjamin D Philpot, Mark J Zylka

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Eric S McCoyDepartment of Cell Biology and Physiology and University of North Carolina Neuroscience Center.
Bonnie Taylor-BlakeDepartment of Cell Biology and Physiology and University of North Carolina Neuroscience Center.
Megumi AitaDepartment of Cell Biology and Physiology and University of North Carolina Neuroscience Center.
Jeremy M SimonDepartment of Cell Biology and Physiology and University of North Carolina Neuroscience Center.ORCID 0000-0003-3906-1663
Benjamin D PhilpotDepartment of Cell Biology and Physiology and University of North Carolina Neuroscience Center.
Mark J ZylkaDepartment of Cell Biology and Physiology and University of North Carolina Neuroscience Center, zylka@med.unc.edu.
Center for Neurosciences · USUniversity of North Carolina at Chapel Hill · USUniversity of North Texas · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2013 to 2019
$8.0M
The Elongation Hypothesis of AutismDP1ES024088 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2013 to 2017
$3.8M
Lipid kinase regulation of pain signaling and sensitizationR01NS081127 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2013 to 2017
$1.6M
Role of UBE3A in the Central Nervous SystemR01NS085093 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PHILPOT, BENJAMIN D · 2014 to 2017
$1.3M
NICHD NIH HHS U54 HD079124NIEHS NIH HHS DP1 ES024088NIEHS NIH HHS P30 ES010126NINDS NIH HHS P30 NS045892NINDS NIH HHS R01 NS081127NINDS NIH HHS R01 NS085093
6 · The paper itself

Abstract

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutation or deletion of the maternal

Indexed as

Disease Models, AnimalAngelman SyndromeAnimalsFemaleGanglia, SpinalMaleMiceMice, KnockoutPain MeasurementSpinal CordUbiquitin-Protein LigasesUbe3a protein, mouseUbiquitin-Protein LigasesAngelman syndromenociceptionUbe3a

Identifiers

PMID28931574
PMCPMC5647775
OpenAlexW2755521263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.