ArticleAmerican journal of Alzheimer's disease and other dementias2018
Learning Metabolic Brain Networks in MCI and AD by Robustness and Leave-One-Out Analysis: An FDG-PET Study.
Article in American journal of Alzheimer's disease and other dementias, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- FDG-PET-based brain network analysis: a brief review of metabolic connectivity.EJNMMI reports · 2025Review
- Stable brain PET metabolic networks using a multiple sampling scheme.Network neuroscience (Cambridge, Mass.) · 2025Article
- A Novel Individual Metabolic Brain Network for 18F-FDG PET Imaging.Frontiers in neuroscience · 2020Article
- Investigation on the Alteration of Brain Functional Network and Its Role in the Identification of Mild Cognitive Impairment.Frontiers in neuroscience · 2020Article
- The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory.Frontiers in aging neuroscience · 2019Article
- A Study on PHF-Tau Network Effected by Apolipoprotein E4.American journal of Alzheimer's disease and other dementiasArticle
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Abstract
This study attempted to better understand the properties associated with the metabolic brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Graph theory was employed to investigate the topological organization of metabolic brain network among 86 patients with MCI, 89 patients with AD, and 97 normal controls (NCs) using 18F fluoro-deoxy-glucose positron emission tomography (FDG-PET) data. The whole brain was divided into 82 areas by Brodmann atlas to construct networks. We found that MCI and AD showed a loss of small-world properties and topological aberrations, and MCI showed an intermediate measurement between NC and AD. The networks of MCI and AD were vulnerable to attacks resulting from the altered topological pattern. Furthermore, individual contributions were correlated with Mini-Mental State Examination and Clinical Dementia Rating. The present study indicated that the topological patterns of the metabolic networks were aberrant in patients with MCI and AD, which may be particularly helpful in uncovering the pathophysiology underlying the cognitive dysfunction in MCI and AD.
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