ArticleThe Journal of infectious diseases2017
The Role of Human Immunodeficiency Virus-Associated Vasculopathy in the Etiology of Stroke.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update.Stroke and vascular neurology · 2023Guideline
- Trends and Clinical Characteristics of HIV and Cerebrovascular Disease in Low- and Middle-Income Countries (LMICs) Between 1990 and 2021.Current HIV/AIDS reports · 2022Pooled it
- Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa.Progress in cardiovascular diseasesPooled it
- Lacunar Infarction as a Neurological Manifestation of Human Immunodeficiency Virus (HIV): A Case Report.Cureus · 2026Article
- Revisiting the Intracranial Neurological Imaging Manifestations of Human Immunodeficiency Virus: Pictorial Review with a Pattern-Based Approach.The Indian journal of radiology & imaging · 2026Article
- The association of premature atherosclerosis with ischemic stroke in young people with HIV in Lusaka, Zambia.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Article
- The association of antiretroviral therapy type and duration of use with stroke in people living with HIV in Zambia.AIDS research and therapy · 2025Article
- The influence of HIV on return to work in stroke survivors amongst a population of the eThekwini district, Kwazulu Natal: A qualitative study.Work (Reading, Mass.) · 2025Article
- The role of atherosclerosis in HIV-associated vasculopathy in young South African stroke patients.HIV medicine · 2025Article
- Local and global stability analysis of HIV/AIDS by using a nonstandard finite difference scheme.Scientific reports · 2025Article
- Exercise to Prevent Accelerated Vascular Aging in People Living With HIV.Circulation research · 2024Review
- Cenicriviroc prevents dysregulation of astrocyte/endothelial cross talk induced by ischemia and HIV-1 via inhibiting the NLRP3 inflammasome and pyroptosis.American journal of physiology. Cell physiology · 2024Article
- The State of Stroke Research in Malawi: Results from a Mapping Review Study.Journal of multidisciplinary healthcare · 2024Review
- Cardioembolic stroke in an HIV endemic region: underdiagnosed and severe.BMJ neurology open · 2024Article
- HIV Infection and 90-Day Stroke Outcomes in Uganda: A Prospective Observational Cohort Study.Neurology. Clinical practice · 2023Article
- Herpes zoster associated with stroke incidence in people living with human immunodeficiency virus: a nested case-control study.BMC infectious diseases · 2023Article
- Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging.The Journal of infectious diseases · 2023Article
- Historical and current issues in HIV encephalitis, and the role of neuropathology in HIV disease: a pathological perspective.Journal of neurology · 2023Review
- Prevalence and Characteristics of HIV-Associated Stroke in a Tertiary Hospital Setting in South Africa.Neurology · 2022Article
- The Body Fat Percentage Rather Than the BMI Is Associated with the CD4 Count among HIV Positive Japanese Individuals.Nutrients · 2022Article
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15 authors at 10 institutions in 4 countries.
Funding
Abstract
Background: Human immunodeficiency virus (HIV) infection is a recognized risk factor for stroke among young populations, but the exact mechanisms are poorly understood. We studied the clinical, radiologic, and histologic features of HIV-related ischemic stroke to gain insight into the disease mechanisms. Methods: We conducted a prospective, in-depth analysis of adult ischemic stroke patients presenting to Queen Elizabeth Central Hospital, Blantyre, Malawi, in 2011. Results: We recruited 64 HIV-infected and 107 HIV-uninfected patients. Those with HIV were significantly younger (P < .001) and less likely to have established vascular risk factors. Patients with HIV were more likely to have large artery disease (21% vs 10%; P < .001). The commonest etiology was HIV-associated vasculopathy (24 [38%]), followed by opportunistic infections (16 [25%]). Sixteen of 64 (25%) had a stroke soon after starting antiretroviral therapy (ART), suggesting an immune reconstitution-like syndrome. In this group, CD4+ T-lymphocyte count was low, despite a significantly lower HIV viral load in those recently started on treatment (P < .001). Conclusions: HIV-associated vasculopathy and opportunistic infections are common causes of HIV-related ischemic stroke. Furthermore, subtypes of HIV-associated vasculopathy may manifest as a result of an immune reconstitution-like syndrome after starting ART. A better understanding of this mechanism may point toward new treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.