SynthesisPloS one2017
Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Multivariate risk assessment and analysis of brain injury in high-risk infants in neonatal intensive care unit.Frontiers in pediatrics · 2026Article
- The effect of hemoglobin level in early life on periventricular leukomalacia: a case control study.Scientific reports · 2025Article
- Two risk assessment models for predicting white matter injury in extremely preterm infants.Pediatric research · 2025Observational
- Prognosis of remaining fetus in twin pregnancy after demise of one fetus according to its location.BMC pregnancy and childbirth · 2024Article
- Infective Endocarditis Requiring Mitral Valve Replacement During Second Trimester of Pregnancy.JACC. Case reports · 2024Article
- White matter protection with insulin-like growth factor-1 after hypoxia-ischaemia in preterm foetal sheep.Brain communications · 2024Article
- Transfontanelle photoacoustic imaging for in-vivo cerebral oxygenation measurement.Scientific reports · 2022Article
- Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits.Cell & bioscience · 2022Article
- The Management of Pregnancy Complicated with the Previable Preterm and Preterm Premature Rupture of the Membranes: What about a Limit of Neonatal Viability?-A Review.Diagnostics (Basel, Switzerland) · 2022Review
- [Sex differences in clinical outcomes of extremely preterm infants/extremely low birth weight infants: a propensity score matching study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Increased Risk for Respiratory Complications in Male Extremely Preterm Infants: A Propensity Score Matching Study.Frontiers in endocrinology · 2022Article
- Mothers with hypertensive disorders of pregnancy increased risk of periventricular leukomalacia in extremely preterm or extremely low birth weight infants: A propensity score analysis.Frontiers in pediatrics · 2022Article
- The association ofFrontiers in neurology · 2022Article
- Newborn metabolic vulnerability profile identifies preterm infants at risk for mortality and morbidity.Pediatric research · 2021Article
- Preventing Brain Injury in the Preterm Infant-Current Controversies and Potential Therapies.International journal of molecular sciences · 2021Review
- Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.Scientific reports · 2020Article
- Connection between gut microbiome and brain development in preterm infants.Developmental psychobiology · 2019Review
- Severe cystic degeneration and intractable seizures in a newborn with molybdenum cofactor deficiency type B.Molecular genetics and metabolism reports · 2019Article
- [A multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Glutamate Transport and Preterm Brain Injury.Frontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough investigators have implicated hypoxic-ischemia (HI) as a potential cause of periventricular leukomalacia (PVL), the role of clinical risk factors or markers for HI in the development of PVL remains controversial. The aim of this study was to identify perinatal HI-related factors associated with PVL.
methodThe PubMed, EMBASE, and Cochrane Library databases were searched. The last search was performed on January 2017. Summary effect estimates (pooled odds ratios [ORs]) were calculated for each risk factor using fixed or random effects models with tests for heterogeneity and publication bias.
resultsFifteen studies with a total of 12,851 participants were included in this meta-analysis, and 14 potential risk factors were analyzed. The pooled results showed that mothers with oligohydramnios (OR, 1.55; 95% confidence interval [CI], 1.05 to 2.30), preterm infants with acidemia (OR, 1.87; 95% CI, 1.18 to 2.97), 1-minute Apgar score <7 (OR 2.69; 95% CI, 1.13 to 6.41), 5-minute Apgar score <7 (OR, 1.89; 95% CI, 1.39 to 2.56), apnea (OR, 1.76; 95% CI, 1.07 to 2.90), respiratory distress syndrome (OR, 1.46; 95% CI, 1.04 to 2.03), and seizures (OR, 4.60; 95% CI, 2.84 to 7.46) were associated with increased risk of PVL.
conclusionThis study identified perinatal HI-related risk factors for the development of PVL in preterm infants. Future large-scale prospective clinical studies are required to validate and extend these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.