ArticleMedicine2017
Infective endocarditis in patients with cancer: a consequence of invasive procedures or a harbinger of neoplasm?: A prospective, multicenter cohort.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Changing Patterns in Infective Endocarditis: A Contemporary Epidemiological Perspective.Pathogens (Basel, Switzerland) · 2026Review
- Review
- Mitral valve prosthesis endocarditis unveiling metastatic colorectal cancer as the primary infection source: a case study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Article
- Infective Endocarditis Following Coil Embolization for a Visceral Pseudoaneurysm: A Case Report.Cureus · 2025Article
- The MEFIER Score-A Risk Score to Stratify Infective Endocarditis in Patients WithOpen forum infectious diseases · 2025Article
- Molecular diagnosis of infective endocarditis from culture-negative valve samples in a tertiary hospital in Iran.Microbiology spectrum · 2025Article
- Infective Endocarditis in Belgium: Prospective Data in Adults from the ESC EORP European Endocarditis Registry.Journal of clinical medicine · 2024Article
- Interventional Cardio-Oncology: Unique Challenges and Considerations in a High-Risk Population.Current treatment options in oncology · 2023Review
- Comparison of trends and outcomes of infective endocarditis in patients with versus without leukemia, 2002 to 2017, from a nationwide inpatient sample.Proceedings (Baylor University. Medical Center) · 2023Article
- Infective Endocarditis: Still More Challenges Than Convictions.Arquivos brasileiros de cardiologia · 2022Article
- Review
- Characteristics of infective endocarditis in a cancer population.Open heart · 2021Article
- Cancer and Infective Endocarditis: Characteristics and Prognostic Impact.Frontiers in cardiovascular medicine · 2021Article
- FDG-PET/CT Incidental Detection of Cancer in Patients Investigated for Infective Endocarditis.Frontiers in medicine · 2020Article
- Article
- Information on nosocomial infections in the mainstream media: an opinion document.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019Article
- Infective Endocarditis in the Elderly: Diagnostic and Treatment Options.Drugs & aging · 2019Review
- A Case of Anterior Spinal Artery Syndrome Caused byCase reports in medicine · 2018Article
- A case of isolated bicuspid pulmonary valve.Echo research and practice · 2017Article
- Overview and Comparison of Infectious Endocarditis and Non-infectious Endocarditis: A Review of 814 Autoptic Cases.In vivo (Athens, Greece)Review
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to draw a comparison between the characteristics of infective endocarditis (IE) in patients with cancer and those of IE in noncancer patients.Patients with IE, according to the modified Duke criteria, were prospectively included in the GAMES registry between January 2008 and February 2014 in 30 hospitals. Patients with active cancer were compared with noncancer patients.During the study period, 161 episodes of IE fulfilled the inclusion criteria. We studied 2 populations: patients whose cancer was diagnosed before IE (73.9%) and those whose cancer and IE were diagnosed simultaneously (26.1%). The latter more frequently had community-acquired IE (67.5% vs 26.4%, P < .01), severe sepsis (28.6% vs 11.1%, P = .013), and IE caused by gastrointestinal streptococci (42.9% vs 16.8%, P < .01). However, catheter source (7.1% vs 29.4%, P = .003), invasive procedures (26.2% vs 44.5%, P = .044), and immunosuppressants (9.5% vs 35.6%, P = .002) were less frequent.When compared with noncancer patients, patients with cancer were more often male (75.2% vs 67.7%, P = .049), with a higher comorbidity index (7 vs 4). In addition, IE was more often nosocomial (48.7% vs 29%) and originated in catheters (23.6% vs 6.2%) (all P < .01). Prosthetic endocarditis (21.7% vs 30.3%, P = .022) and surgery when indicated (24.2% vs 46.5%, P < .01) were less common. In-hospital mortality (34.8% vs 25.8%, P = .012) and 1-year mortality (47.8% vs 30.9%, P < .01) were higher in cancer patients, although 30-day mortality was not (24.8% vs 19.3%, P = .087).A significant proportion of cases of IE (5.6%) were recorded in cancer patients, mainly as a consequence of medical interventions. IE may be a harbinger of occult cancer, particularly that of gastrointestinal or urinary origin.
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