Evidence map›Paper›PMID 28930769›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2017

Acute Alcohol Consumption Directly Increases HIV Transmission Risk: A Randomized Controlled Experiment.

Paul A Shuper, Narges Joharchi, Peter M Monti, Mona Loutfy, Jürgen Rehm

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Paul A Shuper*Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Canada; †Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; ‡Department of Behavioral and Social Sciences, Brown University Center for Alcohol and Addiction Studies, Brown University, Providence, RI; §Women's College Hospital, Toronto, Canada; ‖Department of Medicine, University of Toronto, Toronto, Canada; ¶Maple Leaf Medical Clinic, Toronto, Canada; #Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Canada; **Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada; ††Centre for Addiction and Mental Health, PAHO/WHO Collaborating Centre for Mental Health and Addiction, Toronto, Canada; ‡‡Epidemiological Research Unit, Technische Universität Dresden, Dresden, Germany; §§Klinische Psychologie and Psychotherapie, Dresden, Germany; and ‖‖Graduate Department of Community Health and Institute of Medical Science, University of Toronto, Toronto, Canada.
Narges Joharchi
Peter M Monti
Mona Loutfy
Jürgen Rehm
University of Toronto · CABrown University · USCentre for Addiction and Mental Health · CAKlinik und Poliklinik für Psychotherapie und Psychosomatik · DE

Funding

The Causal Role of Acute Alcohol Consumption in Risky Sex among HIV-Positive MSMR21AA020236 · NIAAA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI SHUPER, PAUL · 2012 to 2013
$274k
CIHR HP111404NIAAA NIH HHS R21 AA020236
6 · The paper itself

Abstract

backgroundAlcohol consumption has frequently been purported as a driver of condomless sex and HIV transmission, but to date, experimental evidence for the causal risk-taking impact of alcohol among HIV-positive populations is lacking. The present experiment sought to determine whether acute alcohol consumption has a direct causal impact on condomless sex intentions among HIV-positive men-who-have-sex-with-men (MSM), and to assess whether alcohol's impact differs between MSM who are HIV-positive versus HIV-negative.

methodsIn a randomized controlled alcohol administration experiment, HIV-positive and HIV-negative MSM were brought into a specialized barroom laboratory and randomly assigned to beverage consumption condition: alcohol (target blood alcohol concentration = 0.080%), placebo alcohol (target blood alcohol concentration = 0.000%), or water (control). Participants then underwent a video-based sexual arousal manipulation (sexually aroused/nonaroused) and indicated their intentions to engage in condom-protected and condomless sexual acts in a standardized paradigm. The primary outcome entailed intentions to engage in condomless receptive and condomless insertive anal sex.

resultsA total of 282 MSM (141 HIV-positive; 141 HIV-negative) completed experimental procedures. MSM who received alcohol reported significantly stronger intentions to engage in condomless sex than those who received placebo alcohol or water (F(1,274) = 9.43, P = 0.002). The impact of alcohol did not differ between HIV-positive and HIV-negative MSM (F(1,274) = 1.86, P = 0.174).

conclusionsThe present investigation entailed the first risk-focused alcohol administration experiment to involve an HIV-positive sample, and results demonstrated that consuming alcohol had an independent, causal impact on intentions to engage in sexual behaviors that can result in HIV transmission. Findings strongly suggest that alcohol-focused initiatives should be incorporated into HIV prevention efforts.

Indexed as

Alcohol DrinkingAdultCondomsHIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedRisk FactorsSexual PartnersUnsafe SexVideo RecordingYoung Adult

Identifiers

PMID28930769
PMCPMC5680134
OpenAlexW2754690639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.