Evidence map›Paper›PMID 28930674›Full record

ArticleCell reports2017

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

Shashi Kant, Claire L Standen, Caroline Morel, Dae Young Jung, Jason K Kim, Wojciech Swat, Richard A Flavell, Roger J Davis

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shashi KantProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: shashi.kant@umassmed.edu.
Claire L StandenProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Caroline MorelProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Dae Young JungProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Jason K KimProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Wojciech SwatDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Richard A FlavellHoward Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Howard Hughes Medical Institute, Worcester, MA 01605, USA. Electronic address: roger.davis@umassmed.edu.
University of Massachusetts Chan Medical School · USHoward Hughes Medical Institute · USWashington University in St. Louis · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
UMass Mouse Metabolic Phenotyping Center - Metabolism CoreU2CDK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2016 to 2021
$4.6M
Adipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4M
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6M
Functional Analysis of the Beta-CellR01DK063368 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J · 2002 to 2006
$2.3M
UMass Mouse Metabolic Phenotyping CenterU24DK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2011 to 2015
$2.1M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS R01 DK063368NIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK112698NIDDK NIH HHS U24 DK093000NIDDK NIH HHS U2C DK093000
6 · The paper itself

Abstract

Obesity is a major risk factor for the development of metabolic syndrome and type 2 diabetes. How obesity contributes to metabolic syndrome is unclear. Free fatty acid (FFA) activation of a non-receptor tyrosine kinase (SRC)-dependent cJun NH

Indexed as

Stress, PhysiologicalAdaptor Proteins, Signal TransducingAnimalsDiet, High-FatEnzyme ActivationInsulin ResistanceJNK Mitogen-Activated Protein KinasesMaleMembrane MicrodomainsMice, Inbred C57BLPalmitatesPhosphorylationPhosphotyrosineProtein Domainssrc-Family KinasesAdaptor Proteins, Signal TransducingJNK Mitogen-Activated Protein KinasesMapk8ip protein, mousePalmitatesPhosphotyrosinesrc-Family Kinasesfatty acidinsulin resistanceJIP1JNK

Identifiers

PMID28930674
PMCPMC5659285
OpenAlexW2754623823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.