ArticleThe international journal of biostatistics2017
Estimation and Inference for the Mediation Proportion.
Article in The international journal of biostatistics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Neighborhood walkability and sex steroid hormone levels in women.Environmental research · 2022Pooled it
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- Adolescent wellbeing is associated with positive outcomes in early adulthood in a sibling comparison study.Nature communications · 2026Article
- Plasma Multiomics Links Early-Life Adversity to Disease and Cardiometabolic Health: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Association between frailty and the risks of chronic pulmonary diseases and lung cancer.BMC pulmonary medicine · 2026Article
- Physical frailty, genetic risk, mediating biomarkers, and risk of suicide attempt: A prospective cohort study.PLoS medicine · 2026Article
- Rationale for incorporating short-term endpoints in interim futility analysis of phase 3 oncology trials: a simulation study.BMC medical research methodology · 2026Article
- SARS-CoV-2 infection during pregnancy and neurodevelopmental outcomes in early childhood.Translational psychiatry · 2026Article
- Circulating fatty acid binding protein 4 (FABP-4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study.International journal of cancer · 2026Article
- Body height and the excess cancer risk in men.International journal of cancer · 2026Article
- Social determinants of health and progression to cardio-renal-metabolic multimorbidity and mortality in people with prediabetes: A prospective cohort study.Diabetes, obesity & metabolism · 2025Observational
- Healthy lifestyle partly mediates the association between self-rated health and risk of overall and cause-specific mortality.BMC medicine · 2025Article
- Adding salt to foods increases the risk of metabolic dysfunction-associated steatotic liver disease.Communications medicine · 2025Article
- Dietary context in the association between red meat consumption and risk of type 2 diabetes.Metabolism: clinical and experimental · 2025Article
- Article
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In epidemiology, public health and social science, mediation analysis is often undertaken to investigate the extent to which the effect of a risk factor on an outcome of interest is mediated by other covariates. A pivotal quantity of interest in such an analysis is the mediation proportion. A common method for estimating it, termed the "difference method", compares estimates from models with and without the hypothesized mediator. However, rigorous methodology for estimation and statistical inference for this quantity has not previously been available. We formulated the problem for the Cox model and generalized linear models, and utilize a data duplication algorithm together with a generalized estimation equations approach for estimating the mediation proportion and its variance. We further considered the assumption that the same link function hold for the marginal and conditional models, a property which we term "g-linkability". We show that our approach is valid whenever g-linkability holds, exactly or approximately, and present results from an extensive simulation study to explore finite sample properties. The methodology is illustrated by an analysis of pre-menopausal breast cancer incidence in the Nurses' Health Study. User-friendly publicly available software implementing those methods can be downloaded from the last author's website (SAS) or from CRAN (R).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.