ArticleBiomacromolecules2017
Biomimetic Stress Sensitive Hydrogel Controlled by DNA Nanoswitches.
Article in Biomacromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- DNA-based hydrogels for bone regeneration: A promising tool for bone organoids.Materials today. Bio · 2025Review
- Hydrogels with reversible stiffness modulation: new materials for studying dynamic mechanical cues that regulate cell behavior.Frontiers in bioengineering and biotechnology · 2025Review
- Three-Dimensional Bioprinting of Naturally Derived Hydrogels for the Production of Biomimetic Living Tissues: Benefits and Challenges.Biomedicines · 2023Review
- Systematic altering of semiflexible DNA-based polymer networksNanoscale · 2023Article
- Advances in Organoid Culture Research.Global medical genetics · 2022Review
- DNA-Helix Inspired Wire Routing in Cylindrical Structures and Its Application to Flexible Surgical Devices.Soft robotics · 2022Article
- Recent Advances in Polymer Additive Engineering for Diagnostic and Therapeutic Hydrogels.International journal of molecular sciences · 2022Review
- Stimuli-responsive DNA-based hydrogels for biosensing applications.Journal of nanobiotechnology · 2022Review
- A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair.Frontiers in bioengineering and biotechnology · 2022Review
- DNA hydrogel-empowered biosensing.Advances in colloid and interface science · 2020Review
- Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels.Frontiers in medicine · 2020Review
- Influence of Network Topology on the Viscoelastic Properties of Dynamically Crosslinked Hydrogels.Frontiers in chemistry · 2020Article
- Stimuli-responsive hydrogels for manipulation of cell microenvironment: From chemistry to biofabrication technology.Progress in polymer science · 2019Article
- Article
- Switchable conformational changes of DNA nanogel shells containing disulfide-DNA hybrids for controlled drug release and efficient anticancer action.RSC advances · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most intriguing and important aspects of biological supramolecular materials is its ability to adapt macroscopic properties in response to environmental cues for controlling cellular processes. Recently, bulk matrix stiffness, in particular, stress sensitivity, has been established as a key mechanical cue in cellular function and development. However, stress-stiffening capacity and the ability to control and exploit this key characteristic is relatively new to the field of biomimetic materials. In this work, DNA-responsive hydrogels, composed of semiflexible PIC polymers equipped with DNA cross-linkers, were engineered to create mimics of natural biopolymer networks that capture these essential elastic properties and can be controlled by external stimuli. We show that the elastic properties are governed by the molecular structure of the cross-linker, which can be readily varied providing access to a broad range of highly tunable soft hydrogels with diverse stress-stiffening regimes. By using cross-linkers based on DNA nanoswitches, responsive to pH or ligands, internal control elements of mechanical properties are implemented that allow for dynamic control of elastic properties with high specificity. The work broadens the current knowledge necessary for the development of user defined biomimetic materials with stress stiffening capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.