Evidence map›Paper›PMID 28930171›Full record

ArticleInternational journal of molecular sciences2017

Comprehensive Evaluation of TFF3 Promoter Hypomethylation and Molecular Biomarker Potential for Prostate Cancer Diagnosis and Prognosis.

Maibritt Nørgaard, Christa Haldrup, Tine Maj Storebjerg, Else Marie Vestergaard, Peter J Wild, Søren Høyer, Michael Borre, Torben Falck Ørntoft, Karina Dalsgaard Sørensen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Identification of a 24-gene panel and a novel marker ofComputational and structural biotechnology journal · 2023
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  14. HOXB13 and TFF3 can contribute to the prognostic stratification of prostate adenocarcinoma.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Maibritt NørgaardDepartment of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. mnj@clin.au.dk.
Christa HaldrupDepartment of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. christa.haldrup@clin.au.dk.
Tine Maj StorebjergDepartment of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. tinestor@rm.dk.
Else Marie VestergaardDepartment of Clinical Genetics, Aarhus University Hospital, 8200 Aarhus N, Denmark. else.marie.vestergaard@clin.au.dk.
Peter J WildInstitute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland. peter.wild@usz.ch.
Søren HøyerDepartment of Histopathology, Aarhus University Hospital, 8200 Aarhus N, Denmark. borre@clin.au.dk.
Michael BorreDepartment of Urology, Aarhus University Hospital, 8200 Aarhus N, Denmark. soren.hoyer@gmail.com.
Torben Falck ØrntoftDepartment of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. Orntoft@clin.au.dk.
Karina Dalsgaard SørensenDepartment of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. kdso@clin.au.dk.ORCID 0000-0002-4902-5490
Aarhus University Hospital · DKUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overdiagnosis and overtreatment of clinically insignificant tumors remains a major problem in prostate cancer (PC) due to suboptimal diagnostic and prognostic tools. Thus, novel biomarkers are urgently needed. In this study, we investigated the biomarker potential of Trefoil factor 3 (

Indexed as

DNA MethylationAdultAgedBiomarkers, TumorCohort StudiesGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMiddle AgedPromoter Regions, GeneticProstateProstatectomyProstatic NeoplasmsTrefoil Factor-3Biomarkers, TumorTFF3 protein, humanTrefoil Factor-3biomarkerdiagnosisDNA methylationexpressionprognosisprostate cancerTFF3

Identifiers

PMID28930171
PMCPMC5618665
OpenAlexW2756210608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.