Evidence map›Paper›PMID 28930071›Full record

ArticleeLife2017

Dynamics of the IFT machinery at the ciliary tip.

Alexander Chien, Sheng Min Shih, Raqual Bower, Douglas Tritschler, Mary E Porter, Ahmet Yildiz

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 154 citations in OpenAlex.

  1. Article
  2. Review
  3. The Trajectory Statistics of Biological Exploratory Dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Regulation of kinesin-2 motility by its β-hairpin motif.Nature structural & molecular biology · 2025
    Article
  10. Article
  11. Intraflagellar transport trains can switch rails and move along multiple microtubules in intact primary cilia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. The intraflagellar transport cycle.Nature reviews. Molecular cell biology · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexander Chien *Biophysics Graduate Group, University of California, Berkeley, Berkeley, United States.ORCID http://orcid.org/0000-0003-1101-6721
Sheng Min Shih *Physics Department, University of California, Berkeley, Berkeley, United States.
Raqual BowerDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States.
Douglas TritschlerDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States.
Mary E PorterDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States.
Ahmet YildizBiophysics Graduate Group, University of California, Berkeley, Berkeley, United States.ORCID http://orcid.org/0000-0003-4792-174X
University of California, Berkeley · USUniversity of Minnesota · US

Funding

Assembly, Targeting, And Regulation Of Dynein MotorsR01GM055667 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PORTER, MARY E. · 1997 to 2023
$5.4M
Super-resolution Microscopy Study of Molecular Transport MechanismsR35GM122552 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Weidong Yang · 2017 to 2026
$4.5M
Assembly , Targeting, and Regulation of Dynein MotorsR37GM055667 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PORTER, MARY E. · 2005 to 2014
$4.0M
Understanding the Mechanism and Regulation of the Human Cytoplasmic Dynein ComplexR01GM094522 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI YILDIZ, AHMET · 2011 to 2019
$2.8M
Structure and Function of the Ciliary Pore ComplexR01GM116204 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VERHEY, KRISTEN J., YANG, WEIDONG · 2015 to 2018
$2.1M
NIGMS NIH HHS R01 GM055667NIGMS NIH HHS R01 GM094522NIGMS NIH HHS R01 GM116204NIGMS NIH HHS R37 GM055667
6 · The paper itself

Abstract

Intraflagellar transport (IFT) is essential for the elongation and maintenance of eukaryotic cilia and flagella. Due to the traffic jam of multiple trains at the ciliary tip, how IFT trains are remodeled in these turnaround zones cannot be determined by conventional imaging. Using PhotoGate, we visualized the full range of movement of single IFT trains and motors in

Indexed as

ChlamydomonasDyneinsFlagellaKinesinsMicroscopy, FluorescenceMicroscopy, VideoProtein TransportDyneinskinesin-IIKinesinsbiophysicscell biologyciliary length controldyneinintraflagellar transportkinesinnonephotogatesingle molecule imagingstructural biology

Identifiers

PMID28930071
PMCPMC5662288
OpenAlexW2952740887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.