Evidence map›Paper›PMID 28930067›Full record

ArticleJournal of studies on alcohol and drugs2017

Prenatal Exposure Effects on Early Adolescent Substance Use: Preliminary Evidence From a Genetically Informed Bayesian Approach.

L Cinnamon Bidwell, Kristine Marceau, Leslie A Brick, Hollis C Karoly, Alexandre A Todorov, Rohan H Palmer, Andrew C Heath, Valerie S Knopik

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of studies on alcohol and drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Disruptive Behavior in Siblings Discordant for Exposure to Maternal Smoking During Pregnancy: A Multi-rater Approach.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

L Cinnamon BidwellInstitute of Cognitive Science, University of Colorado Boulder, Boulder, Colorado.
Kristine MarceauDivision of Behavioral Genetics, Brown University, Providence, Rhode Island.
Leslie A BrickDivision of Behavioral Genetics, Brown University, Providence, Rhode Island.
Hollis C KarolyDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado.
Alexandre A TodorovMidwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Rohan H PalmerDivision of Behavioral Genetics, Brown University, Providence, Rhode Island.
Andrew C HeathMidwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Valerie S KnopikDivision of Behavioral Genetics, Brown University, Providence, Rhode Island.
Brown University · USUniversity of Colorado Boulder · USWashington University in St. Louis · US

Funding

PILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1999 to 2008
$12.6M
RESEARCH TRAINING IN CHILD MENTAL HEALTHT32MH019927 · NIMH · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI Kristen G Benito, Anthony Spirito · 1994 to 2026
$7.8M
MOLECULAR BASIS OF SELECTED GXE EFFECTS IN COMBINED TYPE ADHDR01MH083823 · NIMH · WASHINGTON UNIVERSITY · PI TODOROV, ALEXANDRE A · 2008 to 2012
$3.3M
ALCOHOLISM: GENETIC EPIDEMIOLOGIC TWIN STUDYR01AA009022 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1994 to 2004
$3.3M
GxE in Early Childhood: Twin MothersR01HD049024 · NICHD · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2005 to 2009
$2.9M
Prenatal tobacco exposure: effects on neuropsychological outcomes and ADHDR01DA023134 · NIDA · RHODE ISLAND HOSPITAL · PI KNOPIK, VALERIE S · 2008 to 2013
$2.7M
Genetic Epideniologic Models of Alcohol AbuseR37AA007728 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1998 to 2007
$2.2M
GENE-ENVIRONMENT INTERPLAY IN ALCOHOLISMK05AA017688 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2008 to 2017
$1.9M
NEIGHBORHOOD, FAMILY AND INDIVIDUAL FACTORS IN ADOLESCENT DRINKINGR01AA021492 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C., SCHOOTMAN, MARIO · 2013 to 2016
$1.2M
Bio-behavioral Developmental Origins of Adolescent Substance AbuseK01DA039288 · NIDA · PURDUE UNIVERSITY · PI MARCEAU, KRISTINE · 2016 to 2020
$876k
Deconstructing the Smoking and ADHD Comorbidity: A Multilevel Genetic ApproachK23DA033302 · NIDA · UNIVERSITY OF COLORADO · PI BIDWELL, L. CINNAMON · 2012 to 2016
$871k
Systems Genetics of Alcoholism: Network-based Approaches for Genetics AssociationK01AA021113 · NIAAA · RHODE ISLAND HOSPITAL · PI PALMER, ROHAN HUGH CRAIG · 2012 to 2016
$838k
NCATS NIH HHS L30 TR001045NIAAA NIH HHS K01 AA021113NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA009022NIAAA NIH HHS R01 AA021492NIAAA NIH HHS R37 AA007728NICHD NIH HHS R01 HD049024NIDA NIH HHS K01 DA017671NIDA NIH HHS K01 DA039288NIDA NIH HHS K23 DA033302NIDA NIH HHS R01 DA023134NIMH NIH HHS R01 MH083823NIMH NIH HHS T32 MH019927
6 · The paper itself

Abstract

objectiveGiven the controversy surrounding the question of whether there are direct or causal effects of exposure to maternal smoking during pregnancy (SDP) on offspring outcomes such as substance use during the adolescent years, we sought to test, on a preliminary basis, within- and between-family associations of SDP and initiation of substance use early in adolescence (by age 15 years) using a discordant sibling design.

methodWe used a sibling-comparison approach in a sample of 173 families drawn from the state of Missouri, wherein mothers were discordant for smoking behaviors between two different pregnancies, to test for associations of SDP and initiation of substance use in a younger adolescent cohort. The discordant sibling comparison approach allows for disentangling familial effects from direct effects of SDP through the purposeful collection of data from siblings within the same family with differential exposure.

resultsThere were no between- or within-family effects of SDP on initiation of any type of substance use (alcohol, marijuana, smoking, and other drug classes), suggesting that SDP does not exert a direct effect on substance use in early adolescence.

conclusionsPreliminary findings did not support an association of SDP and initiation of substance use in this younger adolescent sample. Studies such as this one can help build a body of evidence to explain whether associations of SDP and adolescent outcomes reflect a direct effect of SPD or may instead be attributable to familial confounders that are controlled in the discordant sibling design.

Indexed as

AdolescentAdultBayes TheoremCohort StudiesFemaleHumansMaleMissouriMothersPregnancyPrenatal Exposure Delayed EffectsSiblingsSmokingSubstance-Related Disorders

Identifiers

PMID28930067
PMCPMC5675430
OpenAlexW2758310389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.