Evidence map›Paper›PMID 28929836›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging.

Alexander Seiler, Nicholas P Blockley, Ralf Deichmann, Ulrike Nöth, Oliver C Singer, Michael A Chappell, Johannes C Klein, Marlies Wagner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Trial
  2. Article
  3. Article
  4. WSB.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Cortical microstructural involvement in cerebral small vessel disease.Cerebral circulation - cognition and behavior · 2024
    Article
  7. Review
  8. Review
  9. Cerebrovascular development: mechanisms and experimental approaches.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Article
  11. Oxygen metabolism MRI - A comparison with perfusion imaging in a rat model of MCA branch occlusion and reperfusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  12. Article
  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alexander Seiler1 Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany.
Nicholas P Blockley2 Nuffield Department of Clinical Neurosciences, Oxford Center for Functional MRI of the Brain, University of Oxford, Oxford, UK.
Ralf Deichmann3 Brain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany.
Ulrike Nöth3 Brain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany.
Oliver C Singer1 Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany.
Michael A Chappell2 Nuffield Department of Clinical Neurosciences, Oxford Center for Functional MRI of the Brain, University of Oxford, Oxford, UK.
Johannes C Klein5 Nuffield Department of Clinical Neurosciences, Oxford University, and Department of Neurology, Oxford University Hospitals NHS Trust, Oxford, UK.
Marlies Wagner6 Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Goethe University Frankfurt · DEUniversity of Oxford · GBOxford University Hospitals NHS Trust · GB

Funding

Department of HealthParkinson's UK J-0901
6 · The paper itself

Abstract

Oxygenation-sensitive spin relaxation time T2' and relaxation rate R2' (1/T2') are presumed to be markers of the cerebral oxygen extraction fraction (OEF) in acute ischemic stroke. In this study, we investigate the relationship of T2'/R2' with dynamic susceptibility contrast-based relative cerebral blood flow (rCBF) in acute ischemic stroke to assess their plausibility as surrogate markers of the ischemic penumbra. Twenty-one consecutive patients with internal carotid artery and/or middle cerebral artery occlusion were studied at 3.0 T. A physiological model of the cerebral vasculature (VM) was used to process PWI raw data in addition to a conventional deconvolution technique. T2', R2', and rCBF values were extracted from the ischemic core and hypoperfused areas. Within hypoperfused tissue, no correlation was found between deconvolved rCBF and T2' ( r = -0.05, p = 0.788), or R2' ( r = 0.039, p = 0.836). In contrast, we found a strong positive correlation with T2' ( r = 0.444, p = 0.006) and negative correlation with R2' ( r = -0.494, p = 0.0025) for rCBF

Indexed as

Cerebrovascular CirculationAdultAgedAged, 80 and overBrain IschemiaCarotid Artery, InternalFemaleHumansInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMaleMiddle AgedOxygenStrokeOxygenBrain imagingmagnetic resonance imagingoxygen metabolismperfusion-weighted imagingtissue at risk

Identifiers

PMID28929836
PMCPMC6421246
OpenAlexW2754053278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.