Evidence map›Paper›PMID 28929835›Full record

ArticleImmunopharmacology and immunotoxicology2017

DAB

Mahendra K Bhopale, Brendan Hilliard, Cris S Constantinescu, S Michael Phillips, Abdolmohamad Rostami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunopharmacology and immunotoxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mahendra K Bhopalea Department of Radiology , Temple University School of Medicine , Philadelphia , PA , USA.
Brendan Hilliardb Department of Medicine , Temple University School of Medicine , Philadelphia , PA , USA.
Cris S Constantinescuc Division of Clinical Neurology , University of Nottingham , Nottingham , UK.
S Michael Phillipsd Department of Medicine , University of Pennsylvania School of Medicine , Philadelphia , PA , USA.
Abdolmohamad Rostamie Department of Neurology , Thomas Jefferson University , Philadelphia , PA , USA.
Temple University · USThomas Jefferson University · USUniversity of Nottingham · GBUniversity of Pennsylvania · US

Funding

Mechanisms of GM-CSF effect in CNS autoimmune demyelinationR01AI124386 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2017 to 2021
$1.9M
The role of IL-27 in iv tolerance in EAER01AI106026 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI106026NIAID NIH HHS R01 AI124386
6 · The paper itself

Abstract

contextWe have reported previously that DAB389IL-2 recombinant fusion toxin targets IL-2R bearing CD4

objectivesThe present study was undertaken to investigate the effect of DAB389IL-2 treatment on various cytokine-secreting cell populations in A-EAE and C-EAE mice. MATERIALS AND

methodsThe effects of DAB389IL-2 at doses of 200-, 800-, or 1600 kU administered i.v. on days 11-13 and 15 on the clinical score and cytokine-secreting cell populations were examined using flow cytometry.

resultsC-EAE mice treated with 1600kU DAB389IL-2, but not A-EAE mice treated with 800 kU had significantly reduced disease. The CD3+CD25+ sub-population in spleens and spinal cords of A-EAE mice treated with 800 kU DAB389IL-2 a was increased, whereas in C-EAE mice treated with 1600 kU this population was increased. DAB DISCUSSION AND

conclusionsOur study demonstrates that DAB

Indexed as

AnimalsB-LymphocytesCD4-Positive T-LymphocytesDiphtheria ToxinEncephalomyelitis, Autoimmune, ExperimentalFemaleInterferon-gammaInterleukin-10Interleukin-2Lymph NodesLymphocyte ActivationMacrophagesMiceMultiple SclerosisRecombinant Fusion ProteinsSpinal Corddenileukin diftitoxDiphtheria ToxinInterferon-gammaInterleukin-10Interleukin-2Recombinant Fusion ProteinsTumor Necrosis Factor-alphaDAB389IL-2Diphtheria toxinexperimental autoimmune encephalomyelitisinterleukin-2 receptormultiple sclerosis

Identifiers

PMID28929835
PMCPMC5705025
OpenAlexW2756132037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.