ArticleChild development2018
A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder.
Article in Child development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.Biological psychiatry · 2019Pooled it
- Challenging the prescientific frameworks of criminal justice: neurobiology and criminolytic interventions in the legalome era.Frontiers in psychology · 2026Review
- The Multidimensional Dynamic Feedback Model: A Comprehensive Framework for Understanding and Managing Attention-Deficit/Hyperactivity Disorder.Children (Basel, Switzerland) · 2025Review
- Methylome-wide association studies of psychiatric disorders.EC psychology and psychiatry · 2024Article
- Oppositional defiant disorder.Nature reviews. Disease primers · 2023Review
- Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study.Development and psychopathology · 2022Article
- SLC25A24 gene methylation and gray matter volume in females with and without conduct disorder: an exploratory epigenetic neuroimaging study.Translational psychiatry · 2021Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- DNA Methylation inChildren (Basel, Switzerland) · 2021Article
- Review
- DNA methylation in adolescents with anxiety disorder: a longitudinal study.Scientific reports · 2018Article
- Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence.Development and psychopathology · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).
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Registered trials
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