Evidence map›Paper›PMID 28929407›Full record

ArticleJournal of biological physics2017

Gibbs free energy as a measure of complexity correlates with time within C. elegans embryonic development.

Samuel H McGuire, Edward A Rietman, Hava Siegelmann, Jack A Tuszynski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A thermodynamic perspective on mammalian neural crest ingression.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Cooking up the perfect insect: Aristotle's transformational idea about the complete metamorphosis of insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel H McGuireCollege of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Edward A RietmanCollege of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Hava SiegelmannCollege of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Jack A TuszynskiDepartment of Oncology, Cross Cancer Institute, University of Alberta Edmonton, Edmonton, Alberta, Canada. jackt@ualberta.ca.

Funding

Division of Information and Intelligent Systems ECCS-1533693 NSC-FO:
6 · The paper itself

Abstract

We investigate free energy behavior in the nematode Caenorhabditis elegans during embryonic development. Our approach utilizes publicly available gene expression data, which gives us a picture of developmental changes in protein concentration and, resultantly, chemical potential and free energy. Our results indicate a clear global relationship between Gibbs free energy and time spent in development and provide thermodynamic indicators of the large-scale biological events of cell division and differentiation.

Indexed as

AnimalsCaenorhabditis elegansEmbryo, NonmammalianKineticsProtein Interaction MapsThermodynamicsDevelopmentEntropyGibbs free energyProtein-protein interaction networks

Identifiers

PMID28929407
PMCPMC5696307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.