Trial reportJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2017
Effects of toothpastes on white spot lesions around orthodontic brackets using quantitative light-induced fluorescence (QLF) : An in vitro study.
Trial report in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Decoding the periodontitis-coronary artery disease axis through biomarker profiling: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Clinical Applications of Probiotics in Pediatric Dentistry and Orthodontics-A Systematic Review.Nutrients · 2025Pooled it
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- In-vitro and in-vivo comparative studies of treatment effects on enamel demineralization during orthodontic therapy: implications for clinical early-intervention strategy.Clinical oral investigations · 2024Trial
- Use of bioluminescence measurements for detection of artificial demineralization adjacent to orthodontic brackets.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2023Trial
- Prevention of non-cavitated lesions with fluoride and xylitol varnishes during orthodontic treatment: a randomized clinical trial.Clinical oral investigations · 2021Trial
- Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets.Scientific reports · 2020Trial
- Cariogenic Enamel Demineralization Prevention, Detection, and Management: A Literature Review.European journal of dentistry · 2026Article
- Effect of yttrium/lanthanum-doped ultrasonically assisted nano-hydroxyapatite on remineralization and bracket bond strength in artificial enamel lesions.BMC oral health · 2025Article
- Effect of bioactive glass toothpaste on the white spots around orthodontic brackets: A systematic review and meta-analysis.Journal of dental research, dental clinics, dental prospects · 2025Article
- Article
- Effectiveness of fluoride-containing toothpastes associated with different technologies to remineralize enamel after pH cycling: an in vitro study.BMC oral health · 2022Article
- Remineralisation capability of silver diamine fluoride in artificial enamel lesions on smooth surfaces using quantitative light-induced fluorescence measurements in-vitro.Scientific reports · 2022Article
- Current treatment modalities of orthodontically induced white spot lesions and their outcome - a literature review.Medicine and pharmacy reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to investigate the effects of toothpastes with different contents on the remineralization of white spot lesions around orthodontic brackets by quantitative light-induced fluorescence (QLF). MATERIALS AND
methodsA total of 45 freshly extracted human mandibular first molars were selected. Artificial caries lesions were created on enamel surfaces using an acidified gel system for 7 days. Initial relative fluorescence loss was calculated as the pretreatment (baseline) fluorescence value by QLF device. Molar tubes were bonded using light-cured resin composite cement. The specimens were randomly divided into three experimental groups (n = 15). Different toothpastes were applied to demineralized enamel: (1) fluoride-containing toothpaste (Colgate Total
resultsSignificant differences were observed between initial and posttreatment QLF measurements of the demineralized enamel specimens treated with the various agents (p < 0.05). In all experimental groups, significant fluorescence radiance increase and decrease of the lesion area (p = 0.000) was found.
conclusionNovamin-containing toothpaste provided more increase of fluorescence compared to fluoride- and probiotic-containing toothpastes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.