ArticleExperimental brain research2017
Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson's disease.
Article in Experimental brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Visual perturbation training to reduce visual dependency in Parkinson's disease: A randomized controlled trial.PloS one · 2026Trial
- Altered central vestibular processing in Parkinson's disease with Pisa syndrome.Scientific reports · 2026Article
- Glycative Stress Disrupts the Mitochondrial-Lysosome Axis and Promotes Geroconversion in Aging Cardiomyocytes.Aging cell · 2026Article
- Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation.Cellular and molecular neurobiology · 2026Article
- Older adults and individuals with Parkinson's disease control posture along suborthogonal directions that deviate from the traditional anteroposterior and mediolateral directions.Scientific reports · 2024Article
- Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions.Aging and disease · 2024Review
- Vestibular dysfunction in Parkinson's disease: a neglected topic.Frontiers in neurology · 2024Review
- Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE).Behavioral and brain functions : BBF · 2023Article
- Lysosomal dysfunction in neurodegeneration: emerging concepts and methods.Trends in neurosciences · 2022Review
- Effect of galvanic vestibular stimulation on axial symptoms in Parkinson's disease.Journal of central nervous system disease · 2022Review
- Using virtual reality to assess vestibulo-visual interaction in people with Parkinson's disease compared to healthy controls.Experimental brain research · 2021Observational
- SK Channels Modulation Accelerates Equilibrium Recovery in Unilateral Vestibular Neurectomized Rats.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Parkinson mice show functional and molecular changes in the gut long before motoric disease onset.Molecular neurodegeneration · 2021Article
- Suppression head impulse test paradigm (SHIMP) characteristics in people with Parkinson's disease compared to healthy controls.Experimental brain research · 2021Observational
- Static and dynamic otolith reflex function in people with Parkinson's disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Distinct Vestibular Evoked Myogenic Potentials in Patients With Parkinson Disease and Progressive Supranuclear Palsy.Frontiers in neurology · 2020Article
- An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration.Frontiers in neuroscience · 2018Review
- Vestibular Functions and Parkinson's Disease.Frontiers in neurology · 2018Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major cause of morbidity in Parkinson's disease (PD) is postural instability. The neuropathology underlying postural instability is unknown. Postural control is mediated by Deiters' neurons of the lateral vestibular nucleus (LVN), which are the brainstem origin of descending vestibulospinal reflexes. Deiters' neurons express the cytostructural protein, non-phosphorylated neurofilament protein (NPNFP). In PD, reduced expression of NPNFP in substantia nigra (SN) neurons is believed to contribute to dysfunction. It was the aim of this study to determine if there is altered expression of NPNFP in the LVN in PD. We immunolabeled NPNFP in brainstem sections of six aged controls (mean age 92 yo) and six PD donors (mean age 83 yo). Our results show there was a ~ 50% reduction in NPNFP-positive Deiters' neurons compared to controls (13 ± 2.0/section vs 25.7 ± 3.0/section; p < 0.01, repeated measures ANOVA). In contrast, there was no difference in NPNFP-positive counts in the facial nucleus between control and PD. The normalized intensity of NPNFP labeling in LVN was also reduced in PD (0.87 ± 0.05 vs 1.09 ± 0.03; p < 0.01). There was a 35% concurrent reduction in NPNFP-positive neuropil in PD relative to controls (p < 0.01). We also show there was an 84% increase (p < 0.05) in somatic lipofuscin in PD patients compared to control. Lipofuscin aggregation has been shown to increase not only with age but also with neurodegeneration. Furthermore, decreased NPNFP intensity was strongly correlated with increasing lipofuscin autofluorescence across all cases (R
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