Evidence map›Paper›PMID 28929126›Full record

ArticleOpen forum infectious diseases2017

Nasopharyngeal Pneumococcal Density Is Associated With Viral Activity but Not With Use of Improved Stoves Among Young Andean Children.

Leigh M Howard, Roger Fan, Yuwei Zhu, Marie R Griffin, Kathryn M Edwards, Stella Hartinger, John V Williams, Jorge E Vidal, Keith P Klugman, Ana I Gil and 2 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Air Pollution and Global Pediatric Pneumococcal Disease.Open forum infectious diseases · 2025
    Review
  2. Article
  3. Association between nasopharyngeal colonization with multiple pneumococcal serotypes and total pneumococcal colonization density in young Peruvian children.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Article
  4. Article
  5. Article
  6. Is There an Association Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Streptococcus pneumoniae?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Dynamics of Colonization ofOpen forum infectious diseases · 2018
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Leigh M HowardDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Roger FanSchool of Medicine.
Yuwei ZhuDepartment of Biostatistics, and.
Marie R GriffinDepartment of Health Policy, Vanderbilt University, Nashville, Tennessee.
Kathryn M EdwardsDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Stella HartingerUniversidad Peruana Cayetano Heredia, Lima, Peru.
John V WilliamsDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pennsylvania.
Jorge E VidalHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Keith P KlugmanHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Ana I GilInstituto de Investigacion Nutricional, Lima, Peru.
Claudio F LanataDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Carlos G GrijalvaDepartment of Health Policy, Vanderbilt University, Nashville, Tennessee.
Emory University · USInstituto de Investigación Nutricional · PEVanderbilt University · USCancer Research And Biostatistics · USIndiana University School of MedicineSwiss Tropical and Public Health Institute · CHUniversity of Pittsburgh · USVanderbilt Health · USVanderbilt University Medical Center · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
NCRR NIH HHS UL1 RR024975
6 · The paper itself

Abstract

backgroundIndoor smoke exposure is common in developing countries and may influence nasopharyngeal (NP) pneumococcal colonization density and risk of acute respiratory illness. We compared colonization density among Andean children living in households previously enrolled in a randomized controlled trial of a home intervention package including improved stoves to reduce smoke, kitchen sinks, and water disinfection.

methodsWe enrolled 260 children aged <3 years and made weekly household visits to assess for acute respiratory illness (ARI) and collect nasal swabs for respiratory virus polymerase chain reaction (PCR) testing during ARI. At monthly intervals, NP swabs were collected to determine pneumococcal colonization density through quantitative

resultsAge and sociodemographic characteristics were similar between groups. Although no differences were observed in densities between groups, colonization density varied significantly over time in both groups, with highest densities coinciding with spring months. Time during and after virus-associated ARI was also associated with higher pneumococcal colonization density than time remote from ARIs.

conclusionsA home intervention package, including improved stoves, was not associated with changes in pneumococcal densities in young Andean children. However, increasing pneumococcal density was observed with spring season and viral-associated ARIs.

Indexed as

indoor smoke exposurepneumococcal densitypneumococcusrespiratory viruses

Identifiers

PMID28929126
PMCPMC5601081
OpenAlexW2740875853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.