ArticlePeerJ2017
In rats fed high-energy diets, taste, rather than fat content, is the key factor increasing food intake: a comparison of a cafeteria and a lipid-supplemented standard diet.
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Therapeutic effects of bee venom on high fat diet induced obesity and behavioral changes.Biologia futura · 2026Article
- Modulation of PDX1 gene expression and glycemic control by Citrullus lanatus in experimental type 2 diabetes.Scientific reports · 2026Article
- Cafeteria and Fast-Food Diets Induce Neuroinflammation, Social Deficits, but a Different Cardiometabolic Phenotype.Nutrients · 2025Article
- Article
- Article
- Chemical composition, anti-hypertensive properties, and sensory attributes of salt extracted from ash ofFood science & nutrition · 2024Article
- Sex-Dependent Metabolic Effects in Diet-Induced Obese Rats following Intermittent Fasting Compared with Continuous Food Restriction.Nutrients · 2024Article
- Quinoa (Food science & nutrition · 2023Article
- Effects of different diets used to induce obesity/metabolic syndrome on bladder function in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Athrixia phylicoides tea infusion (bushman tea) improves adipokine balance, glucose homeostasis and lipid parameters in a diet-induced metabolic syndrome rat model.BMC complementary medicine and therapies · 2021Article
- Article
- Cafeteria Diet-Induced Metabolic and Cardiovascular Changes in Rats: The Role ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Dietary Energy Partition: The Central Role of Glucose.International journal of molecular sciences · 2020Review
- Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?Nutrition & diabetes · 2020Review
- Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats.Nutrition & metabolism · 2020Article
- The Food Energy/Protein Ratio Regulates the Rat Urea Cycle but Not Total Nitrogen Losses.Nutrients · 2019Article
- Article
- From appetite setpoint to appetition: 50years of ingestive behavior research.Physiology & behavior · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFood selection and ingestion both in humans and rodents, often is a critical factor in determining excess energy intake and its related disorders.
methodsTwo different concepts of high-fat diets were tested for their obesogenic effects in rats; in both cases, lipids constituted about 40% of their energy intake. The main difference with controls fed standard lab chow, was, precisely, the lipid content. Cafeteria diets (K) were self-selected diets devised to be desirable to the rats, mainly because of its diverse mix of tastes, particularly salty and sweet. This diet was compared with another, more classical high-fat (HF) diet, devised not to be as tasty as K, and prepared by supplementing standard chow pellets with fat. We also analysed the influence of sex on the effects of the diets.
resultsK rats grew faster because of a high lipid, sugar and protein intake, especially the males, while females showed lower weight but higher proportion of body lipid. In contrast, the weight of HF groups were not different from controls. Individual nutrient's intake were analysed, and we found that K rats ingested large amounts of both disaccharides and salt, with scant differences of other nutrients' proportion between the three groups. The results suggest that the key differential factor of the diet eliciting excess energy intake was the massive presence of sweet and salty tasting food.
conclusionsThe significant presence of sugar and salt appears as a powerful inducer of excess food intake, more effective than a simple (albeit large) increase in the diet's lipid content. These effects appeared already after a relatively short treatment. The differential effects of sex agree with their different hedonic and obesogenic response to diet.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.