ArticleCase reports in genetics2017
What Drives Embryo Development? Chromosomal Normality or Mitochondria?
Article in Case reports in genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo report the arrest of euploid embryos with high mtDNA content.
designA report of 2 cases.
settingPrivate fertility clinic. PATIENTS: 2 patients, 45 and 40 years old undergoing IVF treatment.
interventionsMature oocytes were collected and vitrified from two ovarian stimulations. Postthaw, survived mature oocytes underwent fertilization by intracytoplasmic sperm injection (ICSI). Preimplantation genetic screening (PGS) and mitochondrial DNA (mtDNA) copy number were done using next generation sequencing (NGS). The only normal embryo among the all-biopsied embryos had the highest "Mitoscore" value and was the only arrested embryo in both cases. Therefore, the embryo transfer was cancelled.
main outcome measuresPostthaw survival and fertilization rate, embryo euploidy, mtDNA copy number, and embryo development.
resultsIn both patients, after PGS only 1 embryo was euploid. Both embryos had the highest mtDNA copy number from all tested embryos and both embryos were arrested on further development.
conclusionsThese cases clearly demonstrate the lack of correlation between mtDNA value (Mitoscore) and chromosomal status of embryo.
Identifiers
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Registered trials
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