ArticleNeural plasticity2017
Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats.
Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Ocular Dominance Plasticity: A Mini-Review.Eye and brain · 2025Review
- Cholinergic modulation of sensory perception and plasticity.Neuroscience and biobehavioral reviews · 2023Review
- NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush.International journal of molecular sciences · 2021Article
- Role of Choline in Ocular Diseases.International journal of molecular sciences · 2021Review
- Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Mesoscopic cortical network reorganization during recovery of optic nerve injury in GCaMP6s mice.Scientific reports · 2020Article
- Article
- Cholinergic nervous system and glaucoma: From basic science to clinical applications.Progress in retinal and eye research · 2019Review
- Cholinergic Potentiation Alters Perceptual Eye Dominance Plasticity Induced by a Few Hours of Monocular Patching in Adults.Frontiers in neuroscience · 2019Article
- Repurposing Alzheimer's disease medications-systemic cholinesterase inhibitors-for the treatment of dry eye syndrome, glaucoma, and age-related macular degeneration.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats. Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals. The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush. Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity. This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.