Evidence map›Paper›PMID 28928775›Full record

ReviewStem cells international2017

Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models.

Tai-Chi Lin, Magdalene J Seiler, Danhong Zhu, Paulo Falabella, David R Hinton, Dennis O Clegg, Mark S Humayun, Biju B Thomas

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
  4. Review
  5. Article
  6. A New Optokinetic Testing Method to Measure Rat Vision.Journal of visualized experiments : JoVE · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tai-Chi LinDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.
Magdalene J SeilerStem Cell Research Center, University of California-Irvine, Irvine, CA, USA.ORCID 0000-0002-0869-9923
Danhong ZhuDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.
Paulo FalabellaDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-8773-7168
David R HintonDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.
Dennis O CleggCenter for Stem Cell Biology and Engineering, University of California, Santa Barbara, CA, USA.
Mark S HumayunDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.
Biju B ThomasDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0312-4450
University of Southern California · USUniversity of California, Irvine · USUniversity of California, Santa Barbara · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction and death of retinal pigment epithelium (RPE) and or photoreceptors can lead to irreversible vision loss. The eye represents an ideal microenvironment for stem cell-based therapy. It is considered an "immune privileged" site, and the number of cells needed for therapy is relatively low for the area of focused vision (macula). Further, surgical placement of stem cell-derived grafts (RPE, retinal progenitors, and photoreceptor precursors) into the vitreous cavity or subretinal space has been well established. For preclinical tests, assessments of stem cell-derived graft survival and functionality are conducted in animal models by various noninvasive approaches and imaging modalities.

Identifiers

PMID28928775
PMCPMC5592015
OpenAlexW2748935543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.