Evidence map›Paper›PMID 28928749›Full record

ArticleFrontiers in immunology2017

FOXO1 Regulates Bacteria-Induced Neutrophil Activity.

Guangyu Dong, Liang Song, Chen Tian, Yu Wang, Fang Miao, Jiabao Zheng, Chanyi Lu, Sarah Alsadun, Dana T Graves

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 51 citations in OpenAlex.

  1. Research progress on the mechanism of FOXO protein in sepsis.Apoptosis : an international journal on programmed cell death · 2026
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  14. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  15. RNA Sequencing Reveals the Upregulation of FOXO Signaling Pathway inInternational journal of molecular sciences · 2022
    Article
  16. Article
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  20. Major Outer Membrane Protein fromJournal of immunology research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Guangyu DongDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Liang SongDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Chen TianDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Yu WangDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Fang MiaoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Jiabao ZhengDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Chanyi LuDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Sarah AlsadunDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Dana T GravesDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
University of Pennsylvania · USStomatology Hospital · CN

Funding

Mechanisms for Impaired Diabetic Wound HealingR01DE019108 · NIDCR · UNIV OF MED/DENT OF NJ-NJ DENTAL SCHOOL · PI DANA T GRAVES · 2009 to 2026
$4.8M
Dendritic Cells and Periodontal DiseaseR01DE021921 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI GRAVES, DANA T · 2012 to 2022
$4.2M
MECHANISMS OF PERIODONTAL DESTRUCTIONR01DE011254 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRAVES, DANA T · 1995 to 2002
$882k
NIDCR NIH HHS R01 DE011254NIDCR NIH HHS R01 DE019108NIDCR NIH HHS R01 DE021921
6 · The paper itself

Abstract

Neutrophils play an essential role in the innate immune response to microbial infection and are particularly important in clearing bacterial infection. We investigated the role of the transcription factor FOXO1 in the response of neutrophils to bacterial challenge with

Indexed as

bacteriaforkheadFOXOFOXO1 overexpressionhost responseinfectioninflammation PMNTLR2

Identifiers

PMID28928749
PMCPMC5591501
OpenAlexW2752696550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.