ArticleFrontiers in systems neuroscience2017
HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model.
Article in Frontiers in systems neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- HDAC3 in Alzheimer's Disease: established evidence, unresolved questions, and translational priorities.Molecular biology reports · 2026Review
- Recommended Tool Compounds: Isoform- and Class-Specific Histone Deacetylase Inhibitors.ACS pharmacology & translational science · 2026Review
- Pharmacological HDAC3 inhibition alters memory updating in young and old male mice.Frontiers in molecular neuroscience · 2024Article
- Learning induces unique transcriptional landscapes in the auditory cortex.Hearing research · 2023Review
- Learning induces unique transcriptional landscapes in the auditory cortex.bioRxiv : the preprint server for biology · 2023Article
- Selective Targeting of Class I HDAC Reduces Microglial Inflammation in the Entorhinal Cortex of Young APP/PS1 Mice.International journal of molecular sciences · 2023Article
- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- Memory Specific to Temporal Features of Sound Is Formed by Cue-Selective Enhancements in Temporal Coding Enabled by Inhibition of an Epigenetic Regulator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Aromatase and nonaromatase neurons in the zebra finch secondary auditory forebrain are indistinct in their song-driven gene induction and intrinsic electrophysiological properties.The European journal of neuroscience · 2021Article
- Sensory cortical and subcortical auditory neurophysiological changes predict cue-specific extinction behavior enabled by the pharmacological inhibition of an epigenetic regulator during memory formation.Brain research bulletin · 2021Article
- Precise memory for pure tones is predicted by measures of learning-induced sensory system neurophysiological plasticity at cortical and subcortical levels.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
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- Testosterone synthesis in the female songbird brain.Hormones and behavior · 2020Article
- Bilateral brain activity in auditory regions is necessary for successful vocal learning in songbirds.Neuroscience letters · 2020Article
- β-adrenergic modulation of discrimination learning and memory in the auditory cortex.The European journal of neuroscience · 2019Article
- Effects of a histone deacetylase 3 inhibitor on extinction and reinstatement of cocaine self-administration in rats.Psychopharmacology · 2019Article
- Rapid and long-lasting improvements in neural discrimination of acoustic signals with passive familiarization.PloS one · 2019Article
- The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Neuroestrogens rapidly shape auditory circuits to support communication learning and perception: Evidence from songbirds.Hormones and behavior · 2018Review
- Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Epigenetic mechanisms that modify chromatin conformation have recently been under investigation for their contributions to learning and the formation of memory. For example, the role of enzymes involved in histone acetylation are studied in the formation of long-lasting memories because memory consolidation requires gene expression events that are facilitated by an open state of chromatin. We recently proposed that epigenetic events may control the entry of specific sensory features into long-term memory by enabling transcription-mediated neuronal plasticity in sensory brain areas. Histone deacetylases, like HDAC3, may thereby regulate the specific sensory information that is captured for entry into long-term memory stores (Phan and Bieszczad, 2016). To test this hypothesis, we used an HDAC3-selective inhibitor (RGFP966) to determine whether its application after an experience with a sound stimulus with unique acoustic features could contribute to the formation of a memory that would assist in mediating its later recognition. We gave adult male zebra finches limited exposure to unique conspecific songs (20 repetitions each, well below the normal threshold to form long-term memory), followed by treatment with RGFP966 or vehicle. In different groups, we either made multi-electrode recordings in the higher auditory area NCM (caudal medial nidopallidum), or determined expression of an immediate early gene,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.