Evidence map›Paper›PMID 28928634›Full record

ReviewFrontiers in cellular neuroscience2017

Transcranial Alternating Current Stimulation (tACS) Mechanisms and Protocols.

Amir V Tavakoli, Kyongsik Yun

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 126 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05188105 nacompletednot on this mapstarted 2021, after this paper: background citation

Interventional Cross-over Study to Evaluate the Efficacy of Transcranial Alternating Current Stimulation (tACS) on Cognitive Performance in Patients With Dementia With Lewy Bodies

TypeinterventionalSponsorAzienda Socio Sanitaria Territoriale degli Spedali Civili di BresciaRan2021 to 2024Enrolled15ConditionsDementia With Lewy Bodies, Lewy Body DiseaseArmsAlpha tACS (12 Hz) over the occipital cortex
NCT06558890 naunknown statusnot on this mapstarted 2024, after this paper: background citation

A Study on the Efficacy and Mechanism of Targeted Cerebellar Transcranial Electrical Stimulation for the Treatment of Refractory Temporal Lobe Epilepsy: A Single-center, Observational Study.

TypeinterventionalSponsorXijing HospitalRan2024 to 2024Enrolled60ConditionsTranscranial Electrical Stimulation, Temporal Lobe Epilepsy, Magnetic Resonance Imaging, ElectroencephalogramArmsTranscranial Alternating Current Stimulation
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  8. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amir V TavakoliDivision of Biology and Biological Engineering, California Institute of TechnologyPasadena, CA, United States.
Kyongsik YunDivision of Biology and Biological Engineering, California Institute of TechnologyPasadena, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perception, cognition and consciousness can be modulated as a function of oscillating neural activity, while ongoing neuronal dynamics are influenced by synaptic activity and membrane potential. Consequently, transcranial alternating current stimulation (tACS) may be used for neurological intervention. The advantageous features of tACS include the biphasic and sinusoidal tACS currents, the ability to entrain large neuronal populations, and subtle control over somatic effects. Through neuromodulation of phasic, neural activity, tACS is a powerful tool to investigate the neural correlates of cognition. The rapid development in this area requires clarity about best practices. Here we briefly introduce tACS and review the most compelling findings in the literature to provide a starting point for using tACS. We suggest that tACS protocols be based on functional brain mechanisms and appropriate control experiments, including active sham and condition blinding.

Indexed as

cognitive performanceneural entrainmentneuromodulationneuroplasticitynoninvasive brain stimulation (NIBS)non-invasive transcranial brain stimulation (NTBS)transcranial alternating current stimulation (tACS)transcranial electrical stimulation (tES)

Identifiers

PMID28928634
PMCPMC5591642

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.