ArticleJournal of food science and technology2017
Recovery from dietary iron deficiency anaemia in rats by the intake of microencapsulated ferric saccharate.
Article in Journal of food science and technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Tolerability of Oral Supplementation with Microencapsulated Ferric Saccharate Compared to Ferrous Sulphate in Healthy Premenopausal Woman: A Crossover, Randomized, Double-Blind Clinical Trial.International journal of molecular sciences · 2022Trial
- Intermittent oral administration of iron oxide nanoparticles modulates iron homeostasis, hematological, inflammatory, and organ-specific responses in iron-deficient rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Comparative study of the effects of different iron sources on bioavailability and gastrointestinal tolerability in iron-deficient rats.Scientific reports · 2025Article
- Iron Administration Partially Ameliorates Cadmium-Induced Oxidative Damage in the Liver and Kidney of Rats.Journal of toxicology · 2024Article
- Antioxidant and Lipid-Lowering Effects of Buriti Oil (Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the bioavailability of iron contained in microencapsulated ferric saccharate in a rat model of iron deficiency anaemia. Three groups of male Sprague-Dawley rats with induced iron deficiency anaemia were subsequently treated with a control Fe-deficient diet (2-6 mg Fe/Kg of diet) with or without the addition of 10 mg Fe/Kg of diet (in form of ferrous sulphate or microencapsulated ferric saccharate) for 2 weeks. The bioavailability of microencapsulated ferric saccharate was examined by measuring body weight gain, feed efficiency and reticulocyte parameters, and compared with the bioavailability of ferrous sulphate. Final body weight, feed efficiency, mean corpuscular volume of reticulocytes and average haemoglobin content in reticulocytes were significantly higher in anaemic rats supplemented with either microencapsulated ferric saccharate or ferrous sulphate, compared to anaemic controls. No significant differences were found between the two iron-supplemented groups. The total number of reticulocytes showed a similar trend. The results demonstrated that ingestion of microencapsulated ferric saccharate is as effective as ferrous sulphate in recovery from iron deficiency anaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.