ArticleScientific reports2017
Molecular dissection of transcriptional reprogramming of steviol glycosides synthesis in leaf tissue during developmental phase transitions in Stevia rebaudiana Bert.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Developmental stage-dependent changes in kaempferol derivatives and associated antioxidant, antibacterial, and quorum sensing inhibitory activities inFood chemistry: X · 2026Article
- The dual role of polyethylene glycol-simulated drought stress inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2026Review
- -Identification of QTL for steviol glycoside biosynthesis using a SNP-based genetic linkage map for Stevia rebaudiana.G3 (Bethesda, Md.) · 2026Article
- Structural, evolutionary and functional insights into the NAC gene family in Stevia rebaudiana and identification of important genes regulating steviol glycosides biosynthesis.BMC plant biology · 2026Article
- Callus culture-derived regeneration and molecular characterization of regeneratedFrontiers in plant science · 2025Article
- High-quality haplotype-resolved chromosome assembly provides evolutionary insights and targeted steviol glycosides (SGs) biosynthesis in Stevia rebaudiana Bertoni.Plant biotechnology journal · 2024Article
- Transcriptomic Analyses Reveal Insights into the Shared Regulatory Network of Phenolic Compounds and Steviol Glycosides inInternational journal of molecular sciences · 2024Article
- De novo transcriptome profiling and development of novel secondary metabolites based genic SSRs in medicinal plant Phyllanthus emblica L. (Aonla).Scientific reports · 2023Article
- The effect of alginate as an elicitor on transcription of steviol glycosides biosynthesis pathway related key genes and sweeteners content in in vitro cultured Stevia rebaudiana.Molecular biology reports · 2023Article
- Spatial Genomic Resource Reveals Molecular Insights into Key Bioactive-Metabolite Biosynthesis in EndangeredInternational journal of molecular sciences · 2022Article
- Comparative transcriptome analysis provides insights into steviol glycoside synthesis in stevia (Stevia rebaudiana Bertoni) leaves under nitrogen deficiency.Plant cell reports · 2021Article
- Synthesis and production of steviol glycosides: recent research trends and perspectives.Applied microbiology and biotechnology · 2021Review
- Functional annotations of ESTs ofSaudi journal of biological sciences · 2021Article
- Health-Promoting Compounds in Stevia: The Effect of Mycorrhizal Symbiosis, Phosphorus Supply and Harvest Time.Molecules (Basel, Switzerland) · 2020Article
- Characterizing glycosyltransferases by a combination of sequencing platforms applied to the leaf tissues of Stevia rebaudiana.BMC genomics · 2020Article
- Comparison of uridine diphosphate-glycosyltransferase UGT76G1 genes from some varieties of Stevia rebaudiana Bertoni.Scientific reports · 2019Article
- Transcriptional profiling of contrasting genotypes revealed key candidates and nucleotide variations for drought dissection in Camellia sinensis (L.) O. Kuntze.Scientific reports · 2019Article
- Validation of reference genes for RT-qPCR studies inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2018Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Stevia is a natural source of commercially important steviol glycosides (SGs), which share biosynthesis route with gibberellic acids (GAs) through plastidal MEP and cytosolic MVA pathways. Ontogeny-dependent deviation in SGs biosynthesis is one of the key factor for global cultivation of Stevia, has not been studied at transcriptional level. To dissect underlying molecular mechanism, we followed a global transcriptome sequencing approach and generated more than 100 million reads. Annotation of 41,262 de novo assembled transcripts identified all the genes required for SGs and GAs biosynthesis. Differential gene expression and quantitative analysis of important pathway genes (DXS, HMGR, KA13H) and gene regulators (WRKY, MYB, NAC TFs) indicated developmental phase dependent utilization of metabolic flux between SGs and GAs synthesis. Further, identification of 124 CYPs and 45 UGTs enrich the genomic resources, and their PPI network analysis with SGs/GAs biosynthesis proteins identifies putative candidates involved in metabolic changes, as supported by their developmental phase-dependent expression. These putative targets can expedite molecular breeding and genetic engineering efforts to enhance SGs content, biomass and yield. Futuristically, the generated dataset will be a useful resource for development of functional molecular markers for diversity characterization, genome mapping and evolutionary studies in Stevia.
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