Evidence map›Paper›PMID 28928398›Full record

ArticleScientific reports2017

Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress.

Die Hu, Zhou-Long Yu, Yan Zhang, Ying Han, Wen Zhang, Lin Lu, Jie Shi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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  6. Dietary NaCellular and molecular life sciences : CMLS · 2023
    Article
  7. Article
  8. Frontiers in psychiatry · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Aldosterone up-regulates basolateral NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  13. Article
  14. Overlapping Molecular Pathways Leading to Autism Spectrum Disorders, Fragile X Syndrome, and Targeted Treatments.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Die HuNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China.
Zhou-Long YuNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China.
Yan ZhangNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China.
Ying HanNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China.
Wen ZhangNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China.ORCID 0000-0001-5166-0736
Lin LuNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China.
Jie ShiNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China. shijie@bjmu.edu.cn.
Peking University · CNMcGovern Institute for Brain Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress is a major risk factor for psychiatric disorders, such as depression, posttraumatic stress disorder, and schizophrenia. Early life stress, such as maternal separation, can have long-term effects on the development of the central nervous system and pathogenesis of psychiatric disorders. In the present study, we found that maternal separation increased the susceptibility to stress in adolescent rats, increased the expression of Na

Indexed as

AnimalsAnimals, NewbornBehavior, AnimalBumetanideFemaleGene Expression RegulationHippocampusK Cl- CotransportersPregnancyRatsReceptors, GABA-ASolute Carrier Family 12, Member 2Stress, PsychologicalSymportersBumetanideK Cl- CotransportersReceptors, GABA-ASlc12a2 protein, ratSolute Carrier Family 12, Member 2Symporters

Identifiers

PMID28928398
PMCPMC5605528
OpenAlexW2756208158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.