Evidence map›Paper›PMID 28928244›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1.

Sangyong Choi, Chaochu Cui, Yanhong Luo, Sun-Hee Kim, Jae-Kyun Ko, Xiaofang Huo, Jianjie Ma, Li-Wu Fu, Rhonda F Souza, Irina Korichneva and 1 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
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  10. PeerJ · 2024
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  20. Esophagus cancer and essential trace elements.Frontiers in public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Sangyong ChoiCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, Texas, USA.
Chaochu CuiCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, Texas, USA.
Yanhong LuoDavis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Sun-Hee KimDavis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Jae-Kyun KoMutagenex, Suwanee, Georgia, USA.
Xiaofang HuoCenter for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott and White Research Institute, Dallas, Texas, USA.
Jianjie MaDavis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Li-Wu FuState Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Rhonda F SouzaCenter for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott and White Research Institute, Dallas, Texas, USA.
Irina KorichnevaDepartment of Pharmacology, University of Picardie Jules Verne, Amiens, France.
Zui PanCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, Texas, USA; zui.pan@uta.edu.
The Ohio State University Wexner Medical Center · USThe University of Texas at Arlington · USBaylor Medical Center at Garland · USBaylor University Medical Center · USChildren's Hospital of Chongqing Medical University · CNSun Yat-sen University · CNTakeda (United States) · USUniversité de Picardie Jules Verne · FR

Funding

Targeting cell membrane repair for treatment of acute kidney injuryR01DK106394 · NIDDK · OHIO STATE UNIVERSITY · PI LIN, PEI-HUI, ROVIN, BRAD H · 2016 to 2020
$2.5M
Oncogenic Function of Ca2+ Channel Orai1 in Esophageal CarcinogenesisR01CA185055 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG, PAN, ZUI · 2015 to 2019
$1.6M
NCI NIH HHS R01 CA185055NIDDK NIH HHS R01 DK106394
6 · The paper itself

Abstract

Zinc, an essential micronutrient, has a cancer preventive role. Zinc deficiency has been shown to contribute to the progression of esophageal cancer. Orai1, a store-operated Ca

Indexed as

Amino Acid SubstitutionCalcium SignalingCarcinoma, Squamous CellCell Line, TumorCell ProliferationChelating AgentsEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEthylenediaminesG2 Phase Cell Cycle CheckpointsGene Knockdown TechniquesHumansModels, BiologicalMutagenesis, Site-DirectedMutant ProteinsORAI1 ProteinChelating AgentsEthylenediaminesMutant ProteinsN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamineORAI1 ProteinORAI1 protein, humanZinccancer preventionhistidineintracellular Ca2+ oscillationsredox sensor

Identifiers

PMID28928244
PMCPMC6207365
OpenAlexW2755760896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.