ArticleScience signaling2017
TALK-1 channels control β cell endoplasmic reticulum Ca
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In one paragraph
Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The diabetes-associated KDiabetologia · 2026Article
- K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Frontiers in pharmacology · 2026Review
- Purinergic CaCancers · 2024Article
- Disrupted Endoplasmic Reticulum CaBiology · 2024Review
- The MODY-associatedeLife · 2024Article
- Purinergic CabioRxiv : the preprint server for biology · 2024Article
- TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet.Cell reports · 2024Article
- Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pH.The Journal of biological chemistry · 2022Article
- Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels.PLoS genetics · 2022Article
- Beta-Cell Ion Channels and Their Role in Regulating Insulin Secretion.Comprehensive Physiology · 2021Review
- Neonatal Diabetes in Patients Affected by Liang-Wang Syndrome Carrying KCNMA1 Variant p.(Gly375Arg) Suggest a Potential Role of CaCurrent issues in molecular biology · 2021Article
- TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation.Development (Cambridge, England) · 2021Article
- A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young.JCI insight · 2021Article
- Lactate activation of α-cell KMolecular metabolism · 2020Article
- Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion.The Journal of physiology · 2020Article
- Ion Channels of the Islets in Type 2 Diabetes.Journal of molecular biology · 2020Review
- The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.Endocrinology · 2020Review
- Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.American journal of physiology. Endocrinology and metabolism · 2019Article
- The machineries, regulation and cellular functions of mitochondrial calcium.Nature reviews. Molecular cell biology · 2018Review
- TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.Molecular metabolism · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Nicholas C VierraDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID http://orcid.org/0000-0001-7269-5399
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Sarah C MilianDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID http://orcid.org/0000-0001-9305-1760
Matthew T DickersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID http://orcid.org/0000-0002-6187-3951
Kelli L JordanDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID http://orcid.org/0000-0002-4219-0143
Patrick GilonPôle d'endocrinologie, diabète et nutrition, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels 1200, Belgium.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. david.a.jacobson@vanderbilt.edu.ORCID http://orcid.org/0000-0003-1816-5375
Vanderbilt University · USUCLouvain · BE
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3MTRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN C · 1986 to 2011
$28.1MMULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MVanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MIntegrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9MTwo-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone SecretionR01DK097392 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2013 to 2022
$3.3MLSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560kSecretagogue Induced Mechanisms Regulating Islet Electrical ActivityK01DK081666 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2009 to 2012
$505kTALK-1 channels as a novel target to modulate basal insulin secretion and obesityF31DK109625 · NIDDK · VANDERBILT UNIVERSITY · PI VIERRA, NICHOLAS CATIN · 2016 to 2017
$42kNCI NIH HHS P30 CA068485NIDDK NIH HHS F31 DK109625NIDDK NIH HHS K01 DK081666NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P60 DK020593NIDDK NIH HHS R01 DK097392NIDDK NIH HHS T32 DK007563NIDDK NIH HHS T32 DK101003NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637NIGMS NIH HHS R25 GM062459NIH HHS S10 OD021630
Abstract
Ca
Indexed as
HomeostasisAnimalsCalciumDiabetes MellitusEndoplasmic ReticulumHEK293 CellsHumansInsulin-Secreting CellsMiceMice, KnockoutPotassium Channels, Tandem Pore DomainCalciumKCNK16 protein, humanPotassium Channels, Tandem Pore Domain
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.