Evidence map›Paper›PMID 28928237›Full record

ArticleScience signaling2017

Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility.

Harry A T Pritchard, Albert L Gonzales, Paulo W Pires, Bernard T Drumm, Eun A Ko, Kenton M Sanders, Grant W Hennig, Scott Earley

Open access · bronzeAbstract read
In one paragraph

Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Impaired intracellular CaScience signaling · 2023
    Article
  3. Uncoupling of CaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. Article
  6. Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Contractile pericytes determine the direction of blood flow at capillary junctions.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Review
  17. Aging, calcium channel signaling and vascular tone.Mechanisms of ageing and development · 2020
    Review
  18. Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  19. Article
  20. CaThe Journal of physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Harry A T PritchardDepartment of Pharmacology, Center for Cardiovascular Research, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.ORCID http://orcid.org/0000-0003-2408-0909
Albert L GonzalesDepartment of Pharmacology, University of Vermont, Burlington, VT 05405, USA.ORCID http://orcid.org/0000-0002-5382-8712
Paulo W PiresDepartment of Pharmacology, Center for Cardiovascular Research, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.ORCID http://orcid.org/0000-0001-5972-4554
Bernard T DrummDepartment of Physiology and Cell Biology, Center for Cardiovascular Research, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Eun A KoDepartment of Physiology and Cell Biology, Center for Cardiovascular Research, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.ORCID http://orcid.org/0000-0002-1585-6886
Kenton M SandersDepartment of Physiology and Cell Biology, Center for Cardiovascular Research, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Grant W HennigDepartment of Pharmacology, University of Vermont, Burlington, VT 05405, USA.
Scott EarleyDepartment of Pharmacology, Center for Cardiovascular Research, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA. searley@med.unr.edu.ORCID http://orcid.org/0000-0001-9560-2941
University of Nevada, Reno · USUniversity of Vermont · US

Funding

Tissue, Cell and Tissue Culture CoreP01DK041315 · NIDDK · UNIVERSITY OF NEVADA RENO · PI RO, SEUNGIL · 1989 to 2018
$26.3M
TRP Channel-Dependent Regulation of Arterial Tone (Renewal)R01HL091905 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2009 to 2020
$5.1M
Inhibitory mechanisms of PDGFRa+ interstitial cells in gastrointestinal motilityR01DK091336 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KURAHASHI, MASAAKI · 2013 to 2022
$4.3M
Sensory mechanisms in brain capillary endothelial cells that initiate functional hyperemiaR01HL139585 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.7M
Structural Basis of Peripheral Coupling Sites Regulating Arterial Smooth Muscle Contractility (A1)R01HL137852 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.6M
Pericyte Control of Junctional Blood FlowK01HL138215 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI GONZALES, ALBERT LOUIS · 2017 to 2021
$744k
NHLBI NIH HHS K01 HL138215NHLBI NIH HHS R01 HL091905NHLBI NIH HHS R01 HL137852NHLBI NIH HHS R01 HL139585NIDDK NIH HHS P01 DK041315NIDDK NIH HHS R01 DK091336
6 · The paper itself

Abstract

Junctional membrane complexes facilitate excitation-contraction coupling in skeletal and cardiac muscle cells by forming subcellular invaginations that maintain close (≤20 nm) proximity of ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR) with voltage-dependent Ca

Indexed as

AnimalsCalcium SignalingLarge-Conductance Calcium-Activated Potassium ChannelsMaleMiceMicrotubulesMuscle ContractionMuscle, Smooth, VascularRatsRats, Sprague-DawleyRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumVasoconstrictionLarge-Conductance Calcium-Activated Potassium Channelsryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelRyR2 protein, rat

Identifiers

PMID28928237
PMCPMC6328376
OpenAlexW2755755862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.