Evidence map›Paper›PMID 28928195›Full record

Trial reportBMJ open2017

REACH: study protocol of a randomised trial of rehabilitation very early in congenital hemiplegia.

Roslyn N Boyd, Jenny Ziviani, Leanne Sakzewski, Iona Novak, Nadia Badawi, Kerstin Pannek, Catherine Elliott, Susan Greaves, Andrea Guzzetta, Koa Whittingham and 8 more

Open access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

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  12. BMJ open · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 3 countries.

Roslyn N BoydQueensland Cerebral Palsy and Rehabilitation Research Centre, Centre for Children's Health Research, The University of Queensland, Brisbane, Australia.
Jenny ZivianiChildren's Allied Health Research, Children's Health Queensland, Brisbane, Queensland, Australia.
Leanne SakzewskiQueensland Cerebral Palsy and Rehabilitation Research Centre, Centre for Children's Health Research, The University of Queensland, Brisbane, Australia.
Iona NovakCerebral Palsy Alliance, The University of Sydney, Sydney, Australia.
Nadia BadawiCerebral Palsy Alliance, The University of Sydney, Sydney, Australia.
Kerstin PannekThe Australian E-Health Research Centre, Health and Biosecurity, CSIRO, Brisbane, Australia.
Catherine ElliottSchool of Occupational Therapy and Social Work, Curtin University, Perth, Australia.
Susan GreavesRoyal Children's Hospital, Melbourne, Australia.
Andrea GuzzettaIRCCS Stella Maris and The University of Pisa, Pisa, Italy.
Koa WhittinghamQueensland Cerebral Palsy and Rehabilitation Research Centre, Centre for Children's Health Research, The University of Queensland, Brisbane, Australia.
Jane ValentinePerth Children's Hospital, Perth, Western Australia, Australia.
Cathy MorganCerebral Palsy Alliance, The University of Sydney, Sydney, Australia.
Margaret WallenCerebral Palsy Alliance, The University of Sydney, Sydney, Australia.
Ann-Christin EliassonDepartment of Women's and Children's Health, Neuropediatric Unit, Karolinska Institutet, Stockholm, Sweden.
Lisa FindlayChildren's Allied Health Research, Children's Health Queensland, Brisbane, Queensland, Australia.
Robert WareMenzies Health Institute Queensland, Griffith University Gold Coast, Nathan, Australia.
Simona FioriIRCCS Stella Maris and The University of Pisa, Pisa, Italy.
Stephen RoseCSIRO Mathematical and Information Sciences Biomedical Imaging Group, Australian e-Health Research Centre.
University of Sydney · AUChildren’s Health Queensland Hospital and Health Service · AUFondazione Stella Maris · ITPerth Children's HospitalUniversity of Queensland · AUAustralian Catholic University · AUAustralian e-Health Research Centre · AUCerebral Palsy Alliance · AUCommonwealth Scientific and Industrial Research Organisation · AUGriffith University · AUKarolinska Institutet · SERoyal Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCongenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study compares the efficacy of infant-friendly modified constraint-induced movement therapy (Baby mCIMT) to infant friendly bimanual therapy (Baby BIM) on upper limb, cognitive and neuroplasticity outcomes in a multisite randomised comparison trial. METHODS AND ANALYSIS: 150 infants (75 in each group), aged between 3 and 6 months ca, with asymmetric brain injury and clinical signs of upper extremity asymmetry will be recruited. Children will be randomised centrally to receive equal doses of either Baby mCIMT or Baby BIM. Baby mCIMT comprises restraint of the unimpaired hand using a simple restraint (eg, glove, sock), combined with intensive parent implemented practice focusing on active use of the impaired hand in a play-based context. In contrast, Baby BIM promotes active play requiring both hands in a play-based context. Both interventions will be delivered by parents at home with monthly home visits and interim telecommunication support by study therapists. Assessments will be conducted at study entry; at 6, 12 months ca immediately postintervention (primary outcome) and 24 months ca (retention). The primary outcome will be the Mini-Assisting Hand Assessment. Secondary outcomes include the Bayley Scale for Infant and Toddler Development (cognitive and motor domains) and the Hand Assessment of Infants. A subset of children will undertake MRI scans at 24 months ca to evaluate brain lesion severity and brain (re)organisation after intervention. ETHICS AND DISSEMINATION: Full ethical approvals for this study have been obtained from the relevant sites. The findings will be disseminated in peer-reviewed publications. TRIAL REGISTRATION NUMBER: Australian and New Zealand Clinical Trials Registry: ACTRN12615000180516, Pre results.

Indexed as

Research DesignBrainChild DevelopmentCognitionExercise Movement TechniquesHemiplegiaHumansInfantMagnetic Resonance ImagingMotor SkillsNeuronal PlasticityPlay and PlaythingsRestraint, PhysicalSingle-Blind MethodUpper Extremitybimanual therapybrain injurycerebral palsycongenital hemiplegiaconstraint induced movement therapyearly interventioninfant

Identifiers

PMID28928195
PMCPMC5623522
OpenAlexW2755484225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.