Evidence map›Paper›PMID 28927699›Full record

ReviewTrends in biochemical sciences2017

Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria.

Kavita J Rangan, Howard C Hang

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. The interplay betweenCell insight · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Frontiers in microbiology · 2024
    Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. A Comparison Study of Age and Colorectal Cancer-Related Gut Bacteria.Frontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kavita J RanganLaboratory of Chemical Biology and Microbial Pathogenesis, ​New York, NY 10065, USA.
Howard C HangLaboratory of Chemical Biology and Microbial Pathogenesis, ​New York, NY 10065, USA. Electronic address: hhang@rockefeller.edu.
Rockefeller University · US

Funding

Immunity and Infectious DiseaseT32AI070084 · NIAID · ROCKEFELLER UNIVERSITY · PI Michel C Nussenzweig · 2008 to 2026
$3.3M
Elucidation of Commensal Bacteria Mechanisms Required for Host ProtectionR01GM103593 · NIGMS · ROCKEFELLER UNIVERSITY · PI HANG, HOWARD C · 2013 to 2020
$2.8M
NIAID NIH HHS T32 AI070084NIGMS NIH HHS R01 GM103593
6 · The paper itself

Abstract

The intestine is a highly complex ecosystem where many bacterial species interact with each other and host cells to influence animal physiology and susceptibility to pathogens. Genomic methods have provided a broad framework for understanding how alterations in microbial communities are associated with host physiology and infection, but the biochemical mechanisms of specific intestinal bacterial species are only emerging. In this review, we focus on recent studies that have characterized the biochemical mechanisms by which intestinal bacteria interact with other bacteria and host pathways to restrict pathogen infection. Understanding the biochemical mechanisms of intestinal microbiota function should provide new opportunities for therapeutic development towards a variety of infectious diseases.

Indexed as

Microbial InteractionsAnimalsBacteriaBacterial InfectionsGastrointestinal MicrobiomeHumansIntestinal MucosaIntestines

Identifiers

PMID28927699
PMCPMC6038137
OpenAlexW2754652167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.