Evidence map›Paper›PMID 28927645›Full record

Observational studyKidney international2018

Angiotensin II Type 1 receptor antibodies are associated with inflammatory cytokines and poor clinical outcomes in pediatric kidney transplantation.

Meghan H Pearl, Qiuheng Zhang, Miguel Fernando Palma Diaz, Jonathan Grotts, Maura Rossetti, David Elashoff, David W Gjertson, Patricia Weng, Elaine F Reed, Eileen Tsai Chambers

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Kidney international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 78 citations in OpenAlex.

  1. Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Trial
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  5. Antibodies to angiotensin II type 1 receptor and endothelin type A receptor are associated with cytokine production enriched for type 2 immune response and antibody production in pediatric kidney transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  6. Article
  7. Review
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  11. Review
  12. Article
  13. Angiotensin II Type-1 Receptor Antibody in Solid Organ Transplantation - Is It Time to Test?Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Emerging monitoring technologies in kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Meghan H PearlDivision of Pediatric Nephrology, UCLA Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: mpearl@mednet.ucla.edu.
Qiuheng ZhangDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Miguel Fernando Palma DiazDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Jonathan GrottsDepartment of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, California, USA.
Maura RossettiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
David ElashoffDepartment of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, California, USA.
David W GjertsonDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Patricia WengDivision of Pediatric Nephrology, UCLA Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, California, USA.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Eileen Tsai ChambersDivision of Pediatric Nephrology, UCLA Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, California, USA; Division of Pediatric Nephrology, Duke University Medical Center, Durham, North Carolina, USA.
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Regulation of Innate Immune Responses by Alloimmunity in Liver Ischemia-Reperfusion InjuryP01AI120944 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Fady M Kaldas · 2017 to 2026
$20.0M
Anti-MHC Effects on EndotheliumR01AI042819 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F · 1999 to 2014
$4.0M
Translational Research Training in Pediatric NephrologyT32DK104687 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALUSKY, ISIDRO B. · 2015 to 2019
$879k
NCATS NIH HHS UL1 TR001881NIAID NIH HHS P01 AI120944NIAID NIH HHS R01 AI042819NIDDK NIH HHS T32 DK104687
6 · The paper itself

Abstract

Angiotensin II type 1 receptor (AT1R) antibody has been linked to poor allograft outcomes in adult kidney transplantation. However, its clinical consequences in children are unknown. To study this, we examined the relationship of AT1R antibody with clinical outcomes, biopsy findings, inflammatory cytokines, and HLA donor-specific antibodies (DSA) in a cohort of pediatric renal transplant recipients. Sixty-five patients were longitudinally monitored for AT1R antibody, HLA DSA, IL-8, TNF-α, IL-1β, IFN-γ, IL-17, and IL-6, renal dysfunction, hypertension, rejection, and allograft loss during the first two years post transplantation. AT1R antibody was positive in 38 of the 65 of children but was not associated with HLA DSA. AT1R antibody was associated with renal allograft loss (odds ratio of 13.1 [95% confidence interval 1.48-1728]), the presence of glomerulitis or arteritis, and significantly higher TNF-α, IL-1β, and IL-8 levels, but not rejection or hypertension. AT1R antibody was associated with significantly greater declines in eGFR in patients both with and without rejection. Furthermore, in patients without rejection, AT1R antibody was a significant risk factor for worsening eGFR over the two-year follow-up period. Thus, AT1R antibody is associated with vascular inflammation in the allograft, progressive decline in eGFR, and allograft loss. AT1R antibody and inflammatory cytokines may identify those at risk for renal vascular inflammation and lead to early biopsy and intervention in pediatric kidney transplantation.

Indexed as

AdolescentAge FactorsAllograftsAutoantibodiesBiomarkersChildCytokinesFemaleGlomerular Filtration RateGraft SurvivalHumansInflammation MediatorsKidney TransplantationLongitudinal StudiesMalePostoperative ComplicationsAGTR1 protein, humanAutoantibodiesBiomarkersCytokinesInflammation MediatorsReceptor, Angiotensin, Type 1angiotensincytokinesendotheliuminflammationpediatric nephrology

Identifiers

PMID28927645
PMCPMC5750071
OpenAlexW2755315906

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.