Evidence map›Paper›PMID 28927644›Full record

Observational studyKidney international2018

Acute kidney injury is a risk factor for subsequent proteinuria.

Sharidan K Parr, Michael E Matheny, Khaled Abdel-Kader, Robert A Greevy, Aihua Bian, James Fly, Guanhua Chen, Theodore Speroff, Adriana M Hung, T Alp Ikizler and 1 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Kidney international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 5 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Pooled it
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  18. Spectrum and Outcome of Acute Kidney Injury in Nonsurgical Cardiac Intensive Care Unit Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sharidan K ParrGeriatric Research Education and Clinical Center, Tennessee Valley Health System Veterans Administration Medical Center, Nashville, Tennessee, USA; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt Center for Kidney Disease and Vanderbilt Integrated Program for AKI Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael E MathenyGeriatric Research Education and Clinical Center, Tennessee Valley Health System Veterans Administration Medical Center, Nashville, Tennessee, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Khaled Abdel-KaderDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt Center for Kidney Disease and Vanderbilt Integrated Program for AKI Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Robert A GreevyDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aihua BianDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
James FlyGeriatric Research Education and Clinical Center, Tennessee Valley Health System Veterans Administration Medical Center, Nashville, Tennessee, USA.
Guanhua ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Theodore SperoffGeriatric Research Education and Clinical Center, Tennessee Valley Health System Veterans Administration Medical Center, Nashville, Tennessee, USA; Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Adriana M HungGeriatric Research Education and Clinical Center, Tennessee Valley Health System Veterans Administration Medical Center, Nashville, Tennessee, USA; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt Center for Kidney Disease and Vanderbilt Integrated Program for AKI Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
T Alp IkizlerDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt Center for Kidney Disease and Vanderbilt Integrated Program for AKI Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Edward D SiewGeriatric Research Education and Clinical Center, Tennessee Valley Health System Veterans Administration Medical Center, Nashville, Tennessee, USA; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt Center for Kidney Disease and Vanderbilt Integrated Program for AKI Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address: edward.siew@vanderbilt.edu.
Vanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · USGeriatric Research Education and Clinical Center · USValley Health System · US

Funding

Enhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Nutrition and Metabolism in Dialysis PatientsK24DK062849 · NIDDK · VANDERBILT UNIVERSITY · PI IKIZLER, TALAT ALP · 2003 to 2012
$1.6M
Developing, Validating, and Implementing a CKD Predictive Model (DELVECKD)K23DK090304 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ABDEL-KADER, KHALED A · 2011 to 2015
$861k
Nutrition, Inflammation and Insulin Resistance in End-Stage Renal DiseaseI01CX000414 · VA · VETERANS HEALTH ADMINISTRATION · PI IKIZLER, TALAT ALP · 2012 to 2015
–
National Surveillance of Acute Kidney Injury Following Cardiac CatheterizationI01HX000853 · VA · VETERANS HEALTH ADMINISTRATION · PI MATHENY, MICHAEL E. · 2013 to 2013
–
Dysmetabolism of Chronic Kidney Disease and Vascular HealthI01CX000982 · VA · VETERANS HEALTH ADMINISTRATION · PI HUNG, ADRIANA · 2015 to 2018
–
CSRD VA I01 CX000414CSRD VA I01 CX000982HSRD VA I01 HX000853HSRD VA I01 HX001280HSRD VA IIR 13-073NCATS NIH HHS UL1 TR000445NIDDK NIH HHS K23 DK090304NIDDK NIH HHS K24 DK062849NIH HHS U2C OD023196
6 · The paper itself

Abstract

Acute kidney injury (AKI) is associated with subsequent chronic kidney disease (CKD), but the mechanism is unclear. To clarify this, we examined the association of AKI and new-onset or worsening proteinuria during the 12 months following hospitalization in a national retrospective cohort of United States Veterans hospitalized between 2004-2012. Patients with and without AKI were matched using baseline demographics, comorbidities, proteinuria, estimated glomerular filtration rate, blood pressure, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker (ACEI/ARB) use, and inpatient exposures linked to AKI. The distribution of proteinuria over one year post-discharge in the matched cohort was compared using inverse probability sampling weights. Subgroup analyses were based on diabetes, pre-admission ACEI/ARB use, and AKI severity. Among the 90,614 matched AKI and non-AKI pairs, the median estimated glomerular filtration rate was 62 mL/min/1.73m

Indexed as

Acute Kidney InjuryAgedAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAntihypertensive AgentsBlood PressureComorbidityDatabases, FactualDiabetes MellitusDiabetic NephropathiesDisease ProgressionFemaleGlomerular Filtration RateHospitalizationHospitals, VeteransHumansAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAntihypertensive Agentsacute kidney injuryalbuminuriaproteinuria

Identifiers

PMID28927644
PMCPMC5796522
OpenAlexW2755586491

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.